Periostin

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Periostin, osteoblast specific factor
Identifiers
SymbolsPOSTN; OSF-2; OSF2; PDLPOSTN; PN; RP11-412K4.1; periostin
External IDsOMIM: 608777 MGI: 1926321 HomoloGene: 4730 GeneCards: POSTN Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1063150706
EnsemblENSG00000133110ENSMUSG00000027750
UniProtQ15063Q62009
RefSeq (mRNA)NM_001135934NM_001198765
RefSeq (protein)NP_001129406NP_001185694
Location (UCSC)Chr 13:
38.14 – 38.17 Mb
Chr 3:
54.36 – 54.39 Mb
PubMed search

Periostin is a protein that in humans is encoded by the POSTN gene.[1][2] Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells.[3]

Clinical significance

In asthma

Periostin is associated with asthma, a fact that is exploited by the experimental asthma medication lebrikizumab.[4]

In cancer

Periostin over-expression was reported in several types of cancer, most frequently in the environment of tumor cells.[3][5] Recent evidence shows that periostin is a component of the extracellular matrix expressed by fibroblasts in normal tissues and stroma of primary tumor. The metastatic colony formation requires the induction of periostin in the foreign stroma by the infiltrating cancer cells. Periostin production is upregulated in lung fibroblasts by either TGF-β2 or TGF-β3, the latter being secreted by infiltrating cancer stem cells (in MMTV-PyMT mouse breast cancer model) [6]

Table: Periostin expression in various cancer cell lines.[7]

Cell line Origin POSTN/ACTB1
U2OS Osteosarcoma 3.5±1.7
LB96 Ewing Sarcoma 0
LB23-1 Rhabdomyosarcoma 0.1±0.1
HeLa Cervical cancer 3.0±0.4
PA-1 Ovarian teratocarcinoma 1.4±0.1
LB37-1 NSCLC 2.8±0.6
LB85 SCLC 3.4±0.2
LB92 SCLC 0.6±0.2
LB1047 Renal cell carcinoma 0.8±0.2
BB64 Renal cell carcinoma 0.08±0.01
LB108 Colorectal cancer 0
MCF7 Breast Cancer 0
Hs578T Breast Cancer 3693±86
Panc-1 Pancreatic carcinoma 0
Capan-1 Pancreatic carcinoma 0
Huh-7 Hepatocarcinoma 0.3±0.07
LB831 Bladder carcinoma 1748±74
MZGC3 Stomach cancer 0
A172 Glioblastoma 45±4
MZ2 Melanoma 2.3±0.7
LB39 Melanoma 0.5±0.03
LB2586-7 Melanoma 3.4±0.3
LB2201-3 Melanoma 4.2±0.4
A375 Melanoma 4.7±1.2

1 (cDNA POSTN/cDNA ACTB) × 104

References

  1. Takeshita S, Kikuno R, Tezuka K, Amann E (Sep 1993). "Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I". Biochem J. 294. ( Pt 1): 271–8. PMC 1134594. PMID 8363580. 
  2. "Entrez Gene: POSTN periostin, osteoblast specific factor". 
  3. 3.0 3.1 Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (Sep 2002). "Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility". Cancer Res 62 (18): 5358–64. PMID 12235007. 
  4. Kraft, M. (2011). "Asthma Phenotypes and Interleukin-13 — Moving Closer to Personalized Medicine". New England Journal of Medicine 365 (12): 1141–1144. doi:10.1056/NEJMe1108666. PMID 21879891. 
  5. Contié S, Voorzanger-Rousselot N, Litvin J, et al. (2011). "Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.". Int. J. Cancer 128 (2): 352–60. doi:10.1002/ijc.25591. PMID 20715172. 
  6. Malanchi I, Santamaria-Martínez A, Susanto E, et al. (2011). "Interactions between cancer stem cells and their niche govern metastatic colonization". Nature 481 (7379): 85–9. doi:10.1038/nature10694. PMID 22158103. 
  7. Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A. (2007). "Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells.". Molecular Cancer 6 (80). doi:10.1186/1476-4598-6-80. PMID 18086302. 

Further reading

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