Pericyazine

Pericyazine

Systematic (IUPAC) name
10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
Clinical data
Pregnancy cat.	C (AU)
Legal status	Prescription Only (S4) (AU) ℞-only (CA) POM (UK)
Routes	Oral
Pharmacokinetic data
Metabolism	Hepatic (mostly via conjugation)[1]
Half-life	12 h[1]
Excretion	Renal[1]
Identifiers
CAS number	2622-26-6
ATC code	N05AC01
PubChem	CID 4747
UNII	3405M6FD73 Y
KEGG	D01485 Y
Chemical data
Formula	C21H23N3OS
Mol. mass	365.49 g/mol
SMILES C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
Y (what is this?)  (verify)

Pericyazine (BAN; also known as periciazine (pINN) or propericiazine) is a medication that belongs to the phenothiazine class of typical antipsychotics. It has also been studied in the treatment of opiate dependence.^[2]

Pericyazine is not approved for sale in the United States. It is commonly sold in Canada under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.^[3]

Medical Uses

The primary uses of pericyazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia.^[1]

Adverse effects

Pericyazine is a rather sedating and anticholinergic antipsychotic and despite being classed with the typical antipsychotics its risk of extrapyramidal side effects is comparatively low.^[4] It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.^[4]

References

External links

• Neulactil - Summary of Product Characteristics from the electronic Medicines Compendium
• from the Therapeutic Goods Administration.
• from Health Canada.