Pan-genome

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In molecular biology a pan-genome (or supra-genome) describes the full complement of genes in a species (typically applied to bacteria and archaea, which can have large variation in gene content among closely related strains). It is the union of the gene sets of all the strains of a species.[1] The significance of the pangenome arises in an evolutionary context, especially with relevance to metagenomics,[2] but is also used in a broader genomics context.[3]

The pan-genome includes the "core genome" containing genes present in all strains, a "dispensable genome" containing genes present in two or more strains, and finally "unique genes" specific to single strains.[1] Note that these distinctions are not strictly biological, since they depend partly on which strains are included in the analysis[citation needed].

See also

References

  1. ↑ 1.0 1.1 Medini D, Donati C, Tettelin H, Masignani V, Rappuoli R (December 2005). "The microbial pan-genome". Curr. Opin. Genet. Dev. 15 (6): 589–94. doi:10.1016/j.gde.2005.09.006. PMID 16185861. 
  2. ↑ Reno ML, Held NL, Fields CJ, Burke PV, Whitaker RJ (May 2009). "Biogeography of the Sulfolobus islandicus pan-genome". Proc. Natl. Acad. Sci. U.S.A. 106 (21): 8605–10. doi:10.1073/pnas.0808945106. PMC 2689034. PMID 19435847. 
  3. ↑ Reinhardt JA, Baltrus DA, Nishimura MT, Jeck WR, Jones CD, Dangl JL (February 2009). "De novo assembly using low-coverage short read sequence data from the rice pathogen Pseudomonas syringae pv. oryzae". Genome Res. 19 (2): 294–305. doi:10.1101/gr.083311.108. PMC 2652211. PMID 19015323. 
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