PVRL3
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Poliovirus receptor-related 3 (nectin-3), also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.[1]
Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][1]
See also
Interactions
PVRL3 has been shown to interact with MLLT4,[2][3] PARD3,[4] and PTPmu (PTPRM).[5]
References
- ↑ 1.0 1.1 "Entrez Gene: PVRL3 poliovirus receptor-related 3".
- ↑ Satoh-Horikawa, K; Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (April 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. (UNITED STATES) 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. ISSN 0021-9258. PMID 10744716.
- ↑ Reymond, N; Borg J P, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (September 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene (NETHERLANDS) 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. ISSN 0378-1119. PMID 11024295.
- ↑ Takekuni, Kyoji; Ikeda Wataru, Fujito Tsutomu, Morimoto Koji, Takeuchi Masakazu, Monden Morito, Takai Yoshimi (February 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. (United States) 278 (8): 5497–500. doi:10.1074/jbc.C200707200. ISSN 0021-9258. PMID 12515806.
- ↑ Sakamoto Y, Ogita H, Komura H, Takai Y (2008). "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion". J Biol Chem 283 (1): 496–505. doi:10.1074/jbc.M704195200. PMID 17965016.
Further reading
- Satoh-Horikawa K, Nakanishi H, Takahashi K et al. (2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716.
- Reymond N, Borg JP, Lecocq E et al. (2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. PMID 11024295.
- Fabre S, Reymond N, Cocchi F et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Takekuni K, Ikeda W, Fujito T et al. (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
- Mueller S, Wimmer E (2003). "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains". J. Biol. Chem. 278 (33): 31251–60. doi:10.1074/jbc.M304166200. PMID 12759359.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Fujito T, Ikeda W, Kakunaga S et al. (2005). "Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3". J. Cell Biol. 171 (1): 165–73. doi:10.1083/jcb.200501090. PMC 2171219. PMID 16216929.
External links
- PVRL3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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