PTRF
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| Polymerase I and transcript release factor | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PTRF; CAVIN; CAVIN1; CGL4; cavin-1 | ||||||||||||
| External IDs | OMIM: 603198 MGI: 1277968 HomoloGene: 7499 GeneCards: PTRF Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 284119 | 19285 | |||||||||||
| Ensembl | ENSG00000177469 | ENSMUSG00000004044 | |||||||||||
| UniProt | Q6NZI2 | O54724 | |||||||||||
| RefSeq (mRNA) | NM_012232 | NM_008986 | |||||||||||
| RefSeq (protein) | NP_036364 | NP_033012 | |||||||||||
| Location (UCSC) | Chr 17: 40.55 – 40.58 Mb | Chr 11: 100.96 – 100.97 Mb | |||||||||||
| PubMed search | |||||||||||||
Polymerase I and transcript release factor, also known as PTRF, is a protein which in humans is encoded by the PTRF gene.[1]
Function
Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.[2][3]
PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.[4]
Interactions
PTRF has been shown to interact with ZNF148.[5]
References
- ↑ "Entrez Gene: PTRF polymerase I and transcript release factor".
- ↑ Mason SW, Sander EE, Grummt I (January 1997). "Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I". The EMBO Journal 16 (1): 163–72. doi:10.1093/emboj/16.1.163. PMC 1169623. PMID 9009277.
- ↑ Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (May 1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". The EMBO Journal 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
- ↑ Aboulaich N, Vainonen JP, Strålfors P, Vener AV (October 2004). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". The Biochemical journal 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
- ↑ Hasegawa, T; Takeuchi A, Miyaishi O, Xiao H, Mao J, Isobe K (April 2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". Biochem. J. (ENGLAND). 347 Pt 1 (Pt 1): 55–9. doi:10.1042/0264-6021:3470055. ISSN 0264-6021. PMC 1220930. PMID 10727401.
Further reading
- Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". EMBO J. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
- Hasegawa T, Takeuchi A, Miyaishi O, et al. (2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". Biochem. J. 347 Pt 1 (Pt 1): 55–9. doi:10.1042/0264-6021:3470055. PMC 1220930. PMID 10727401.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
- Aboulaich N, Ortegren U, Vener AV, Strålfors P (2006). "Association and insulin regulated translocation of hormone-sensitive lipase with PTRF". Biochem. Biophys. Res. Commun. 350 (3): 657–61. doi:10.1016/j.bbrc.2006.09.094. PMID 17026959.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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