PSMD8

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

Identifiers

PSMD8; HIP6; HYPF; Nin1p; Rpn12; S14; p31

External IDs

MGI: 1888669 HomoloGene: 37686 GeneCards: PSMD8 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• proteasome complex • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • proteasome regulatory particle • proteasome accessory complex
Biological process	• cell cycle checkpoint • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • M phase of mitotic cell cycle • mitotic anaphase • protein polyubiquitination • mitotic cell cycle • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of cellular amino acid metabolic process • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • gene expression • viral reproduction • RNA metabolic process • mRNA metabolic process • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cellular nitrogen compound metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I • regulation of apoptotic process • small molecule metabolic process • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
38.87 – 38.87 Mb

Chr 7:
29.17 – 29.18 Mb

PubMed search

26S proteasome non-ATPase regulatory subunit 8 is an enzyme that in humans is encoded by the PSMD8 gene.^[1]^[2]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.^[2]

References

↑ Kominami K, DeMartino GN, Moomaw CR, Slaughter CA, Shimbara N, Fujimuro M, Yokosawa H, Hisamatsu H, Tanahashi N, Shimizu Y, et al. (Aug 1995). "Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae". EMBO J 14 (13): 3105–15. PMC 394372. PMID 7621825.
↑ 2.0 2.1 "Entrez Gene: PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8".

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PSMD8

References

Further reading