PSMD11

From Wikipedia, the free encyclopedia

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

Identifiers

PSMD11; Rpn6; S9; p44.5

External IDs

OMIM: 604449 MGI: 1916327 HomoloGene: 2108 GeneCards: PSMD11 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• proteasome complex • nucleoplasm • cytosol • proteasome accessory complex
Biological process	• cell cycle checkpoint • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • M phase of mitotic cell cycle • mitotic anaphase • protein polyubiquitination • mitotic cell cycle • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • ubiquitin-dependent protein catabolic process • regulation of cellular amino acid metabolic process • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • gene expression • viral reproduction • RNA metabolic process • mRNA metabolic process • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cellular nitrogen compound metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I • regulation of apoptotic process • proteasome assembly • small molecule metabolic process • stem cell differentiation • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
30.77 – 30.81 Mb

Chr 11:
80.43 – 80.47 Mb

PubMed search

26S proteasome non-ATPase regulatory subunit 11 is an enzyme that in humans is encoded by the PSMD11 gene.^[1]^[2]^[3]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator.^[3]

References

↑ Saito A, Watanabe TK, Shimada Y, Fujiwara T, Slaughter CA, DeMartino GN, Tanahashi N, Tanaka K (Jan 1998). "cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome". Gene 203 (2): 241–50. doi:10.1016/S0378-1119(97)00524-6. PMID 9426256.
↑ Hoffman L, Rechsteiner M (Apr 1997). "Molecular cloning and expression of subunit 9 of the 26S proteasome". FEBS Lett 404 (2–3): 179–84. doi:10.1016/S0014-5793(97)00126-9. PMID 9119060.
↑ 3.0 3.1 "Entrez Gene: PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11".

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PSMD11

References

Further reading