PSMC1

From Wikipedia, the free encyclopedia
Proteasome (prosome, macropain) 26S subunit, ATPase, 1
Identifiers
SymbolsPSMC1; P26S4; S4; p56
External IDsOMIM: 602706 MGI: 106054 HomoloGene: 2095 GeneCards: PSMC1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez570019179
EnsemblENSG00000100764ENSMUSG00000021178
UniProtP62191P62192
RefSeq (mRNA)NM_002802NM_008947
RefSeq (protein)NP_002793NP_032973
Location (UCSC)Chr 14:
90.72 – 90.74 Mb		Chr 12:
100.11 – 100.12 Mb
PubMed search
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26S protease regulatory subunit 4 is an enzyme that in humans is encoded by the PSMC1 gene.[1][2]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.[2]

Interactions

PSMC1 has been shown to interact with PSMD2[3][4] and PSMC2.[4][5]

References

  1. ↑ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K (March 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509. 
  2. ↑ 2.0 2.1 "Entrez Gene: PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1". 
  3. ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ↑ 4.0 4.1 Gorbea, C; Taillandier D, Rechsteiner M (January 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J. Biol. Chem. (UNITED STATES) 275 (2): 875–82. doi:10.1074/jbc.275.2.875. ISSN 0021-9258. PMID 10625621. 
  5. ↑ Hartmann-Petersen, R; Tanaka K, Hendil K B (February 2001). "Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking". Arch. Biochem. Biophys. (United States) 386 (1): 89–94. doi:10.1006/abbi.2000.2178. ISSN 0003-9861. PMID 11361004. 

Further reading

  • Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes.". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196. 
  • Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1.". Cell 114 (3): 281–3. doi:10.1016/S0092-8674(03)00602-0. PMID 12914693. 
  • Dubiel W, Ferrell K, Pratt G, Rechsteiner M (1992). "Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family.". J. Biol. Chem. 267 (32): 22699–702. PMID 1429620. 
  • Winkelmann DA, Kahan L (1983). "Immunochemical accessibility of ribosomal protein S4 in the 30 S ribosome. The interaction of S4 with S5 and S12.". J. Mol. Biol. 165 (2): 357–74. doi:10.1016/S0022-2836(83)80261-7. PMID 6188845. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem. 272 (13): 8145–8. doi:10.1074/jbc.272.13.8145. PMID 9079628. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Dai RM, Chen E, Longo DL, et al. (1998). "Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha". J. Biol. Chem. 273 (6): 3562–73. doi:10.1074/jbc.273.6.3562. PMID 9452483. 
  • Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein". J. Virol. 72 (12): 10251–5. PMC 110608. PMID 9811770. 
  • Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577. 
  • Gorbea C, Taillandier D, Rechsteiner M (2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J. Biol. Chem. 275 (2): 875–82. doi:10.1074/jbc.275.2.875. PMID 10625621. 
  • Zhang Z, Torii N, Furusaka A, et al. (2000). "Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex". J. Biol. Chem. 275 (20): 15157–65. doi:10.1074/jbc.M910378199. PMID 10748218. 
  • Mulder LC, Muesing MA (2000). "Degradation of HIV-1 integrase by the N-end rule pathway". J. Biol. Chem. 275 (38): 29749–53. doi:10.1074/jbc.M004670200. PMID 10893419. 
  • Turnell AS, Grand RJ, Gorbea C, et al. (2000). "Regulation of the 26S proteasome by adenovirus E1A". EMBO J. 19 (17): 4759–73. doi:10.1093/emboj/19.17.4759. PMC 302057. PMID 10970867. 
  • Hartmann-Petersen R, Tanaka K, Hendil KB (2001). "Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking". Arch. Biochem. Biophys. 386 (1): 89–94. doi:10.1006/abbi.2000.2178. PMID 11361004. 
  • Matilla A, Gorbea C, Einum DD, et al. (2002). "Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex". Hum. Mol. Genet. 10 (24): 2821–31. doi:10.1093/hmg/10.24.2821. PMID 11734547. 
  • Sheehy AM, Gaddis NC, Choi JD, Malim MH (2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein". Nature 418 (6898): 646–50. doi:10.1038/nature00939. PMID 12167863. 
  • Huang X, Seifert U, Salzmann U, et al. (2002). "The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing". J. Mol. Biol. 323 (4): 771–82. doi:10.1016/S0022-2836(02)00998-1. PMID 12419264. 


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