POU4F3
From Wikipedia, the free encyclopedia
| POU class 4 homeobox 3 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | POU4F3; BRN3C; DFNA15 | ||||||||||||
| External IDs | OMIM: 602460 MGI: 102523 HomoloGene: 2023 GeneCards: POU4F3 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5459 | 18998 | |||||||||||
| Ensembl | ENSG00000091010 | ENSMUSG00000024497 | |||||||||||
| UniProt | Q15319 | Q63955 | |||||||||||
| RefSeq (mRNA) | NM_002700 | NM_138945 | |||||||||||
| RefSeq (protein) | NP_002691 | NP_620395 | |||||||||||
| Location (UCSC) | Chr 5: 145.72 – 145.72 Mb | Chr 18: 42.39 – 42.4 Mb | |||||||||||
| PubMed search | |||||||||||||
POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.[1][2]
References
- ↑ Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB (Apr 1998). "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans". Science 279 (5358): 1950–4. doi:10.1126/science.279.5358.1950. PMID 9506947.
- ↑ "Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3".
Further reading
- Nolan LS, Jagutpal SS, Cadge BA, et al. (2007). "Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.". Gene 400 (1–2): 89–97. doi:10.1016/j.gene.2007.05.023. PMID 17611044.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Clough RL, Sud R, Davis-Silberman N, et al. (2004). "Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity". Biochem. Biophys. Res. Commun. 324 (1): 372–81. doi:10.1016/j.bbrc.2004.09.074. PMID 15465029.
- Weiss S, Gottfried I, Mayrose I, et al. (2003). "The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity". Mol. Cell. Biol. 23 (22): 7957–64. doi:10.1128/MCB.23.22.7957-7964.2003. PMC 262385. PMID 14585957.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Leonard JH, Cook AL, Van Gele M, et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". Int. J. Cancer 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986.
- Erkman L, McEvilly RJ, Luo L, et al. (1996). "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development". Nature 381 (6583): 603–6. doi:10.1038/381603a0. PMID 8637595.
- Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.
External links
- POU4F3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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