POU3F2

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POU class 3 homeobox 2
Identifiers
SymbolsPOU3F2; BRN2; N-Oct3; OCT7; OTF-7; OTF7; POUF3; brn-2; oct-7
External IDsOMIM: 600494 MGI: 101895 HomoloGene: 4095 ChEMBL: 4189 GeneCards: POU3F2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez545418992
EnsemblENSG00000184486ENSMUSG00000095139
UniProtP20265P31360
RefSeq (mRNA)NM_005604NM_008899
RefSeq (protein)NP_005595NP_032925
Location (UCSC)Chr 6:
99.28 – 99.29 Mb
Chr 4:
22.48 – 22.49 Mb
PubMed search

POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.[1][2]

N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM][2]

Interactions

POU3F2 has been shown to interact with PQBP1.[3]

See also

References

  1. Schreiber E, Tobler A, Malipiero U, Schaffner W, Fontana A (Mar 1993). "cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif". Nucleic Acids Res 21 (2): 253–8. doi:10.1093/nar/21.2.253. PMC 309100. PMID 8441633. 
  2. 2.0 2.1 "Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2". 
  3. Waragai, M; Lammers C H, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian M M, Okazawa H (Jun 1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet. (ENGLAND) 8 (6): 977–87. doi:10.1093/hmg/8.6.977. ISSN 0964-6906. PMID 10332029. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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