POLR2G

From Wikipedia, the free encyclopedia
Polymerase (RNA) II (DNA directed) polypeptide G

PDB rendering based on 2c35.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsPOLR2G; RPB19; RPB7; hRPB19; hsRPB7
External IDsOMIM: 602013 MGI: 1914960 HomoloGene: 2019 GeneCards: POLR2G Gene
EC number2.7.7.6
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez543667710
EnsemblENSG00000168002ENSMUSG00000071662
UniProtP62487P62488
RefSeq (mRNA)NM_002696NM_026329
RefSeq (protein)NP_002687NP_080605
Location (UCSC)Chr 11:
62.53 – 62.53 Mb
Chr 19:
8.79 – 8.8 Mb
PubMed search

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.[1][2]

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.[3]

Interactions

POLR2G has been shown to interact with TAF15,[4] POLR2C,[5] POLR2H[5] and POLR2E.[5]

References

  1. Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). "Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology". Mol Biol Cell 6 (7): 759–75. PMC 301239. PMID 7579693. 
  2. Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). "Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization". Biochim Biophys Acta 1353 (1): 39–49. PMID 9256063. 
  3. "Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G". 
  4. Bertolotti, A; Melot T, Acker J, Vigneron M, Delattre O, Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489–97. ISSN 0270-7306. PMC 108863. PMID 9488465. 
  5. 5.0 5.1 5.2 Acker, J; de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. (UNITED STATES) 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 

Further reading


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