POLD1

From Wikipedia, the free encyclopedia
Polymerase (DNA directed), delta 1, catalytic subunit
Identifiers
SymbolsPOLD1; CDC2; CRCS10; POLD
External IDsOMIM: 174761 MGI: 97741 HomoloGene: 2014 ChEMBL: 2735 GeneCards: POLD1 Gene
EC number2.7.7.7
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez542418971
EnsemblENSG00000062822ENSMUSG00000038644
UniProtP28340P52431
RefSeq (mRNA)NM_001256849NM_011131
RefSeq (protein)NP_001243778NP_035261
Location (UCSC)Chr 19:
50.89 – 50.92 Mb
Chr 7:
44.53 – 44.55 Mb
PubMed search

DNA polymerase delta catalytic subunit is an enzyme that in humans is encoded by the POLD1 gene.[1][2] It is a component of the DNA polymerase delta complex.

POLD1, along with POLE (enzyme), has recently been associated with multiple adenoma.[3]

References

Further reading

  • Kemper RR, Ahn ER, Zhang P, et al. (1992). "Human DNA polymerase delta gene maps to region 19q13.3-q13.4 by in situ hybridization.". Genomics 14 (1): 205–6. doi:10.1016/S0888-7543(05)80311-8. PMID 1427831. 
  • Yang CL, Chang LS, Zhang P, et al. (1992). "Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta.". Nucleic Acids Res. 20 (4): 735–45. doi:10.1093/nar/20.4.735. PMC 312012. PMID 1542570. 
  • Popanda O, Thielmann HW (1992). "The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.". Biochim. Biophys. Acta 1129 (2): 155–60. doi:10.1016/0167-4781(92)90480-N. PMID 1730053. 
  • Lee MY, Toomey NL (1987). "Human placental DNA polymerase delta: identification of a 170-kilodalton polypeptide by activity staining and immunoblotting.". Biochemistry 26 (4): 1076–85. doi:10.1021/bi00378a014. PMID 2436659. 
  • Dresler SL, Gowans BJ, Robinson-Hill RM, Hunting DJ (1989). "Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.". Biochemistry 27 (17): 6379–83. doi:10.1021/bi00417a028. PMID 3146346. 
  • Nishida C, Reinhard P, Linn S (1988). "DNA repair synthesis in human fibroblasts requires DNA polymerase delta.". J. Biol. Chem. 263 (1): 501–10. PMID 3335506. 
  • Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2).". Genomics 44 (1): 45–51. doi:10.1006/geno.1997.4838. PMID 9286699. 
  • Wu SM, Zhang P, Zeng XR, et al. (1998). "Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins.". J. Biol. Chem. 273 (16): 9561–9. doi:10.1074/jbc.273.16.9561. PMID 9545286. 
  • Coll JM, Hickey RJ, Cronkey EA, et al. (1998). "Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.". Oncol. Res. 9 (11-12): 629–39. PMID 9563011. 
  • Fox G, Popanda O, Thielmann HW (1998). "Evidence for reduced copying fidelity of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells.". J. Cancer Res. Clin. Oncol. 123 (11-12): 659–68. doi:10.1007/s004320050121. PMID 9620226. 
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806. 
  • Mo J, Liu L, Leon A, et al. (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA.". Biochemistry 39 (24): 7245–54. doi:10.1021/bi0000871. PMID 10852724. 
  • Budworth H, Dianova II, Podust VN, Dianov GL (2002). "Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine.". J. Biol. Chem. 277 (24): 21300–5. doi:10.1074/jbc.M201918200. PMID 11923315. 
  • Ohta S, Shiomi Y, Sugimoto K, et al. (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929. 
  • Smith RW, Nasheuer HP (2002). "Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.". FEBS Lett. 527 (1-3): 143–6. doi:10.1016/S0014-5793(02)03197-6. PMID 12220650. 
  • Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.". Biochim. Biophys. Acta 1578 (1-3): 59–72. doi:10.1016/S0167-4781(02)00497-9. PMID 12393188. 
  • Xie B, Mazloum N, Liu L, et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.". Biochemistry 41 (44): 13133–42. doi:10.1021/bi0262707. PMID 12403614. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Shevelev IV, Ramadan K, Hübscher U (2004). "The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.". ScientificWorldJournal 2: 275–81. doi:10.1100/tsw.2002.99. PMID 12806015. 


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