PNU-142633
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| PNU-142633 | ||
|---|---|---|
 | ||
| IUPAC name (S)-1-(2-(4-(4-Carbamoylphenyl)piperazin-1-yl)ethyl)-N-methylisochroman-6-carboxamide | ||
| Other names PNU-142633F | ||
| Identifiers | ||
| CAS number | 187665-65-2  , 249765-69-3 (maleate) | |
| Jmol-3D images | {{#if:NC(C(C=C1)=CC=C1N2CCN(CC[C@@H]3OCCC4=C3C=CC(C(NC)=O)=C4)CC2)=O|Image 1 | |
| ||
| Properties | ||
| Molecular formula | C24H30N4O3 | |
| Molar mass | 422.52 g mol−1 | |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
PNU-142633 is an experimental drug candidate for the treatment of migraine. It exerts its effect as a selective, high affinity 5-HT1D receptor antagonist.[1][2] PNU-142633 is well tolerated after oral administration.[3]
References
- ↑ Pregenzer, JF; Alberts, GL; Im, WB; Slightom, JL; Ennis, MD; Hoffman, RL; Ghazal, NB; Tenbrink, RE (1999). "Differential pharmacology between the guinea-pig and the gorilla 5-HT1D receptor as probed with isochromans (5-HT1D-selective ligands)". British journal of pharmacology 127 (2): 468–72. doi:10.1038/sj.bjp.0702532. PMC 1566017. PMID 10385247.
- ↑ PNU 142633, Santa Cruz Biotechnology
- ↑ Fleishaker, JC; Pearson, LK; Knuth, DW; Gomez-Mancilla, B; Francom, SF; McIntosh, MJ; Freestone, S; Azie, NE (1999). "Pharmacokinetics and tolerability of a novel 5-HT1D agonist, PNU-142633F". International journal of clinical pharmacology and therapeutics 37 (10): 487–92. PMID 10543315.
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