PLDN

From Wikipedia, the free encyclopedia
Biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Identifiers
SymbolsBLOC1S6; BLOS6; HPS9; PA; PALLID; PLDN
External IDsOMIM: 604310 MGI: 1927580 HomoloGene: 40841 GeneCards: BLOC1S6 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2625818457
EnsemblENSG00000104164ENSMUSG00000005804
UniProtQ9UL45Q9R0C0
RefSeq (mRNA)NM_012388NM_019788
RefSeq (protein)NP_036520NP_062762
Location (UCSC)Chr 15:
45.88 – 45.91 Mb
Chr 2:
122.74 – 122.75 Mb
PubMed search

Pallidin is a protein that in humans is encoded by the PLDN gene.[1][2]

The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

Interactions

PLDN has been shown to interact with BLOC1S1,[3] STX12,[1] Dysbindin,[3] CNO,[3] BLOC1S2,[3] MUTED[3][4] and SNAPAP.[3]

References

  1. 1.0 1.1 Huang L, Kuo YM, Gitschier J (Dec 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nat Genet 23 (3): 329–32. doi:10.1038/15507. PMID 10610180. 
  2. 2.0 2.1 "Entrez Gene: PLDN pallidin homolog (mouse)". 
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Starcevic, Marta; Dell'Angelica Esteban C (Jul 2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)". J. Biol. Chem. (United States) 279 (27): 28393–401. doi:10.1074/jbc.M402513200. ISSN 0021-9258. PMID 15102850. 
  4. Falcón-Pérez, Juan M; Starcevic Marta, Gautam Rashi, Dell'Angelica Esteban C (Aug 2002). "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules". J. Biol. Chem. (United States) 277 (31): 28191–9. doi:10.1074/jbc.M204011200. ISSN 0021-9258. PMID 12019270. 

Further reading


This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.