PITPNM1
From Wikipedia, the free encyclopedia
| Phosphatidylinositol transfer protein, membrane-associated 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PITPNM1; DRES9; NIR2; PITPNM; RDGB; RDGB1; RDGBA; RDGBA1; Rd9 | ||||||||||||
| External IDs | OMIM: 608794 MGI: 1197524 HomoloGene: 3608 ChEMBL: 1764937 GeneCards: PITPNM1 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9600 | 18739 | |||||||||||
| Ensembl | ENSG00000110697 | ENSMUSG00000024851 | |||||||||||
| UniProt | O00562 | O35954 | |||||||||||
| RefSeq (mRNA) | NM_001130848 | NM_001136078 | |||||||||||
| RefSeq (protein) | NP_001124320 | NP_001129550 | |||||||||||
| Location (UCSC) | Chr 11: 67.26 – 67.27 Mb | Chr 19: 4.1 – 4.11 Mb | |||||||||||
| PubMed search | |||||||||||||
Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.[1][2]
PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM][2]
Interactions
PITPNM1 has been shown to interact with PTK2B.[3]
References
- ↑ Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (Aug 1998). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct 1 (3): 205–13. PMID 9680295.
- ↑ 2.0 2.1 "Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".
- ↑ Lev, S; Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. (UNITED STATES) 19 (3): 2278–88. ISSN 0270-7306. PMC 84020. PMID 10022914.
Further reading
- Vihtelic TS, Hyde DR, O'Tousa JE (1991). "Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene.". Genetics 127 (4): 761–8. PMC 1204403. PMID 1903119.
- Aikawa Y, Hara H, Watanabe T (1997). "Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene.". Biochem. Biophys. Res. Commun. 236 (3): 559–64. doi:10.1006/bbrc.1997.7009. PMID 9245688.
- Lev S, Hernandez J, Martinez R, et al. (1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.". Mol. Cell. Biol. 19 (3): 2278–88. PMC 84020. PMID 10022914.
- Tian D, Litvak V, Toledo-Rodriguez M, et al. (2002). "Nir2, a novel regulator of cell morphogenesis.". Mol. Cell. Biol. 22 (8): 2650–62. doi:10.1128/MCB.22.8.2650-2662.2002. PMC 133726. PMID 11909959.
- Litvak V, Tian D, Carmon S, Lev S (2002). "Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.". Mol. Cell. Biol. 22 (14): 5064–75. doi:10.1128/MCB.22.14.5064-5075.2002. PMC 139767. PMID 12077336.
- Litvak V, Shaul YD, Shulewitz M, et al. (2003). "Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain.". Curr. Biol. 12 (17): 1513–8. doi:10.1016/S0960-9822(02)01107-7. PMID 12225667.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Litvak V, Argov R, Dahan N, et al. (2004). "Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion.". Mol. Cell 14 (3): 319–30. doi:10.1016/S1097-2765(04)00214-X. PMID 15125835.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Amarilio R, Ramachandran S, Sabanay H, Lev S (2005). "Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction.". J. Biol. Chem. 280 (7): 5934–44. doi:10.1074/jbc.M409566200. PMID 15545272.
- Ocaka L, Spalluto C, Wilson DI, et al. (2005). "Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3.". Cytogenet. Genome Res. 108 (4): 293–302. doi:10.1159/000081519. PMID 15627748.
- Litvak V, Dahan N, Ramachandran S, et al. (2005). "Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function.". Nat. Cell Biol. 7 (3): 225–34. doi:10.1038/ncb1221. PMID 15723057.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Burgis NE, Cunningham RP (2007). "Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.". J. Biol. Chem. 282 (6): 3531–8. doi:10.1074/jbc.M608708200. PMID 17090528.
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.