PHF21A

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PHD finger protein 21A

Rendering based on PDB 2PUY.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsPHF21A; BHC80
External IDsOMIM: 608325 HomoloGene: 9597 GeneCards: PHF21A Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez51317192285
EnsemblENSG00000135365ENSMUSG00000058318
UniProtQ96BD5Q6ZPK0
RefSeq (mRNA)NM_001101802NM_001109690
RefSeq (protein)NP_001095272NP_001103160
Location (UCSC)Chr 11:
45.95 – 46.14 Mb
Chr 2:
92.09 – 92.36 Mb
PubMed search

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.[1][2][3]

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM][3]

Interactions

PHF21A has been shown to interact with HMG20B,[2][4] HDAC1,[2][4] Histone deacetylase 2[2][4][5] and RCOR1.[2][4]

References

  1. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  2. 2.0 2.1 2.2 2.3 2.4 Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core–BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc Natl Acad Sci U S A 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298. 
  3. 3.0 3.1 "Entrez Gene: PHF21A PHD finger protein 21A". 
  4. 4.0 4.1 4.2 4.3 Iwase, Shigeki; Januma Aya, Miyamoto Kiyoko, Shono Naomi, Honda Arata, Yanagisawa Junn, Baba Tadashi (Sep 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. (United States) 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. ISSN 0006-291X. PMID 15325272. 
  5. Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. (United States) 278 (9): 7234–9. doi:10.1074/jbc.M208992200. ISSN 0021-9258. PMID 12493763. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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