PHF17
From Wikipedia, the free encyclopedia
| PHD finger protein 17 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PHF17; JADE1 | ||||||||||||
| External IDs | OMIM: 610514 MGI: 1925835 HomoloGene: 18162 GeneCards: PHF17 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 79960 | 269424 | |||||||||||
| Ensembl | ENSG00000077684 | ENSMUSG00000025764 | |||||||||||
| UniProt | Q6IE81 | Q6ZPI0 | |||||||||||
| RefSeq (mRNA) | NM_024900 | NM_001130184 | |||||||||||
| RefSeq (protein) | NP_079176 | NP_001123656 | |||||||||||
| Location (UCSC) | Chr 4: 129.73 – 129.8 Mb | Chr 3: 41.56 – 41.62 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein Jade-1 is a protein that in humans is encoded by the PHF17 gene.[1][2][3]
Interactions
PHF17 has been shown to interact with Beta-catenin[4] and Von Hippel-Lindau tumor suppressor.[2]
References
- ↑ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
- ↑ 2.0 2.1 Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT (Oct 2002). "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1". J Biol Chem 277 (42): 39887–98. doi:10.1074/jbc.M205040200. PMID 12169691.
- ↑ "Entrez Gene: PHF17 PHD finger protein 17".
- ↑ Chitalia, Vipul C; Foy Rebecca L, Bachschmid Markus M, Zeng Liling, Panchenko Maria V, Zhou Mina I, Bharti Ajit, Seldin David C, Lecker Stewart H, Dominguez Isabel, Cohen Herbert T (Oct 2008). "Jade-1 inhibits Wnt signaling by ubiquitinating β-catenin and mediates Wnt pathway inhibition by pVHL". Nat. Cell Biol. (England) 10 (10): 1208–16. doi:10.1038/ncb1781. PMC 2830866. PMID 18806787.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tzouanacou E, Tweedie S, Wilson V (2003). "Identification of Jade1, a Gene Encoding a PHD Zinc Finger Protein, in a Gene Trap Mutagenesis Screen for Genes Involved in Anteroposterior Axis Development". Mol. Cell. Biol. 23 (23): 8553–2. doi:10.1128/MCB.23.23.8553-8562.2003. PMC 262661. PMID 14612400.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Panchenko MV, Zhou MI, Cohen HT (2005). "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity". J. Biol. Chem. 279 (53): 56032–41. doi:10.1074/jbc.M410487200. PMID 15502158.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Zhou MI, Foy RL, Chitalia VC, et al. (2005). "Jade-1, a candidate renal tumor suppressor that promotes apoptosis". Proc. Natl. Acad. Sci. U.S.A. 102 (31): 11035–40. doi:10.1073/pnas.0500757102. PMC 1182408. PMID 16046545.
- Doyon Y, Cayrou C, Ullah M, et al. (2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Mol. Cell 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- PHF17 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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