PEX14
From Wikipedia, the free encyclopedia
Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.[1][2]
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[2]
Interactions
PEX14 has been shown to interact with
References
- ↑ Fransen M, Terlecky SR, Subramani S (Aug 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proc Natl Acad Sci U S A 95 (14): 8087–92. doi:10.1073/pnas.95.14.8087. PMC 20933. PMID 9653144.
- ↑ 2.0 2.1 "Entrez Gene: PEX14 peroxisomal biogenesis factor 14".
- ↑ 3.0 3.1 Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (March 2002). "Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import". Mol. Cell. Biol. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
- ↑ Okumoto K, Abe I, Fujiki Y (August 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". J. Biol. Chem. 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480.
- ↑ Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (April 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". J. Biol. Chem. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238.
- ↑ 6.0 6.1 Managadze D, Würtz C, Sichting M, Niehaus G, Veenhuis M, Rottensteiner H (June 2007). "The peroxin PEX14 of Neurospora crassa is essential for the biogenesis of both glyoxysomes and Woronin bodies". Traffic 8 (6): 687–701. doi:10.1111/j.1600-0854.2007.00560.x. PMID 17461798.
Further reading
- Albertini M, Rehling P, Erdmann R et al. (1997). "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways". Cell 89 (1): 83–92. doi:10.1016/S0092-8674(00)80185-3. PMID 9094717.
- Huhse B, Rehling P, Albertini M et al. (1998). "Pex17p of Saccharomyces cerevisiae Is a Novel Peroxin and Component of the Peroxisomal Protein Translocation Machinery". J. Cell Biol. 140 (1): 49–60. doi:10.1083/jcb.140.1.49. PMC 2132588. PMID 9425153.
- Will GK, Soukupova M, Hong X et al. (1999). "Identification and Characterization of the Human Orthologue of Yeast Pex14p". Mol. Cell. Biol. 19 (3): 2265–77. PMC 84019. PMID 10022913.
- Girzalsky W, Rehling P, Stein K et al. (1999). "Involvement of Pex13p in Pex14p Localization and Peroxisomal Targeting Signal 2–dependent Protein Import into Peroxisomes". J. Cell Biol. 144 (6): 1151–62. doi:10.1083/jcb.144.6.1151. PMC 2150583. PMID 10087260.
- Shimizu N, Itoh R, Hirono Y et al. (1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". J. Biol. Chem. 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238.
- Sacksteder KA, Jones JM, South ST et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
- Gavva NR, Wen SC, Daftari P et al. (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor". Genomics 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.
- Otera H, Setoguchi K, Hamasaki M et al. (2002). "Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import". Mol. Cell. Biol. 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
- Alland L, David G, Shen-Li H et al. (2002). "Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex". Mol. Cell. Biol. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
- Fransen M, Brees C, Ghys K et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell Proteomics 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Oliveira ME, Reguenga C, Gouveia AM et al. (2003). "Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction". Biochim. Biophys. Acta 1567 (1–2): 13–22. PMID 12488033.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Fransen M, Vastiau I, Brees C et al. (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". J. Biol. Chem. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
- Shimozawa N, Tsukamoto T, Nagase T et al. (2004). "Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene". Hum. Mutat. 23 (6): 552–8. doi:10.1002/humu.20032. PMID 15146459.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nguyen T, Bjorkman J, Paton BC, Crane DI (2006). "Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance". J. Cell. Sci. 119 (Pt 4): 636–45. doi:10.1242/jcs.02776. PMID 16449325.
External links
- GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
- OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
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