PEX11B
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| Peroxisomal biogenesis factor 11 beta | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PEX11B; PEX11-BETA; PEX14B | ||||||||||||
| External IDs | OMIM: 603867 MGI: 1338882 HomoloGene: 2852 GeneCards: PEX11B Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8799 | 18632 | |||||||||||
| Ensembl | ENSG00000131779 | ENSMUSG00000028102 | |||||||||||
| UniProt | O96011 | Q9Z210 | |||||||||||
| RefSeq (mRNA) | NM_001184795 | NM_001162387 | |||||||||||
| RefSeq (protein) | NP_001171724 | NP_001155859 | |||||||||||
| Location (UCSC) | Chr 1: 145.52 – 145.52 Mb | Chr 3: 96.64 – 96.65 Mb | |||||||||||
| PubMed search | |||||||||||||
Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene.[1][2] It is involved in the regulation of peroxisome abundance. [3]
Interactions
PEX11B has been shown to interact with PEX19.[4][5]
Related gene problems
References
- ↑ Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem 273 (45): 29607–14. doi:10.1074/jbc.273.45.29607. PMID 9792670.
- ↑ "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".
- ↑ Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.". FEBS J 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949.
- ↑ Sacksteder, K A; Jones J M, South S T, Li X, Liu Y, Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. (UNITED STATES) 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444.
- ↑ Fransen, M; Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. (United States) 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669.
- ↑ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.
Further reading
- Abe I, Fujiki Y (1998). "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p". Biochem. Biophys. Res. Commun. 252 (2): 529–33. doi:10.1006/bbrc.1998.9684. PMID 9826565.
- Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
- Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell Proteomics 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Li X, Gould SJ (2003). "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11". J. Biol. Chem. 278 (19): 17012–20. doi:10.1074/jbc.M212031200. PMID 12618434.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Exp. Cell Res. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615.
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