PCGF1

From Wikipedia, the free encyclopedia

Polycomb group ring finger 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4HPL, 4HPM

Identifiers

PCGF1; 2010002K04Rik; NSPC1; RNF3A-2; RNF68

External IDs

OMIM: 610231 MGI: 1917087 HomoloGene: 13090 GeneCards: PCGF1 Gene

Gene Ontology
Molecular function	• protein binding • protein C-terminus binding • zinc ion binding
Cellular component	• nucleus • nucleolus • PcG protein complex
Biological process	• transcription, DNA-dependent • regulation of transcription, DNA-dependent • histone H2A monoubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000115289

ENSMUSG00000069678

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
74.73 – 74.74 Mb

Chr 6:
83.08 – 83.08 Mb

PubMed search

Polycomb group RING finger protein 1 is a protein that in humans is encoded by the PCGF1 gene.^[1]^[2]

References

↑ Nunes M, Blanc I, Maes J, Fellous M, Robert B, McElreavey K (Apr 2001). "NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system". Mech Dev 102 (1–2): 219–22. doi:10.1016/S0925-4773(01)00288-X. PMID 11287196.
↑ "Entrez Gene: PCGF1 polycomb group ring finger 1".

Further reading

Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M (2004). "Stem cells and cancer; the polycomb connection". Cell 118 (4): 409–18. doi:10.1016/j.cell.2004.08.005. PMID 15315754.
Gong Y, Yue J, Wu X, et al. (2007). "NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element". Nucleic Acids Res. 34 (21): 6158–69. doi:10.1093/nar/gkl834. PMC 1693893. PMID 17088287.
Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ (2006). "Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets". Mol. Cell. Biol. 26 (18): 6880–9. doi:10.1128/MCB.00630-06. PMC 1592854. PMID 16943429.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gong Y, Wang X, Liu J, et al. (2005). "NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183". FEBS Lett. 579 (1): 115–21. doi:10.1016/j.febslet.2004.11.056. PMID 15620699.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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