Overlapping gene

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An overlapping gene is a gene whose expressible nucleotide sequence partially overlaps with the expressible nucleotide sequence of another gene.[1] In this way, a nucleotide sequence may make a contribution to the function of one or more gene products. The shared nucleotide sequence may be read in alternate reading frames during transcription of different genes, or (in double-stranded DNA), part of the antisense strand of one gene may form part of the sense strand of a different gene. They have been found in multiple domains of life, including bacteria, viruses and higher eukaryotes, including humans.[2]

References

  1. ↑ Y. Fukuda, M. Tomita et T. Washio (1999). "Comparative study of overlapping genes in the genomes of Mycoplasma genitalium and Mycoplasma pneumoniae". Nucl. Acids Res. (Oxford Journals) 27 (8): 1847–1853. doi:10.1093/nar/27.8.1847. 
  2. ↑ C. Sanna, W. Li et L. Zhang (2008). "Overlapping genes in the human and mouse genomes". BMC Genomics 9 (169). doi:10.1186/1471-2164-9-169. 



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