Oncomodulin

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Oncomodulin is a calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells.

Cell signaling: calcium signaling / calcium metabolism

Cell membrane

Ion pumps	SERCA Sodium-calcium exchanger

Cell membrane calcium channels	VDCC TRP NMDA receptor AMPA receptor 5-HT3 receptor P2X purinoreceptor

Adhesion molecules	Cadherin

Other	Calcium-sensing receptor

Intracellular signaling
& calc. regulation

Second messengers	IP3 NAADP cADPR

Store gates (ligand-gated calcium channel)	IP3 receptor CICR Ryanodine receptor

Molecular switches, and kinases	Troponin C Calmodulin CaM kinases PKC NCS

Chelators and calcium sensors	Calbindin S100 pervalbumin Calretinin Calsequestrin Sarcalumenin Phospholamban Synaptotagmins

Proteases	Calpain

Cytoskeleton remodeling proteins	Gelsolin

Chaperones	Calreticulin Calnexin

Other	Vitamin D

Calcium-binding
protein domains

Extracellular ligands

Calcium-binding proteins

Intracellular calcium-sensing proteins	Calmodulin Calnexin Calreticulin Gelsolin neuronal Hippocalcin Neurocalcin Recoverin

Membrane protein	Annexin A1 A2 A5 Fibulin FBLN1 FBLN2 FBLN5 Vitamin D-dependent calcium-binding protein/Calbindin Calexcitin Calsequestrin Osteocalcin Osteonectin S-100 Synaptotagmin

Cytoskeleton	Troponin C

Extracellular matrix	Matrix gla protein

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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