OTUB2
From Wikipedia, the free encyclopedia
| OTU domain, ubiquitin aldehyde binding 2 | |||||||||||||
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 PDB rendering based on 1tff. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | OTUB2; C14orf137; OTB2; OTU2 | ||||||||||||
| External IDs | OMIM: 608338 MGI: 1915399 HomoloGene: 57056 GeneCards: OTUB2 Gene | ||||||||||||
| EC number | 3.4.19.12 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 78990 | 68149 | |||||||||||
| Ensembl | ENSG00000089723 | ENSMUSG00000021203 | |||||||||||
| UniProt | Q96DC9 | Q9CQX0 | |||||||||||
| RefSeq (mRNA) | NM_023112 | NM_001177841 | |||||||||||
| RefSeq (protein) | NP_075601 | NP_001171312 | |||||||||||
| Location (UCSC) | Chr 14: 94.49 – 94.52 Mb | Chr 12: 103.39 – 103.41 Mb | |||||||||||
| PubMed search | |||||||||||||
Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.[1][2]
Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.[2]
References
- ↑ Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
- ↑ 2.0 2.1 "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".
Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Nanao MH, Tcherniuk SO, Chroboczek J, et al. (2005). "Crystal structure of human otubain 2.". EMBO Rep. 5 (8): 783–8. doi:10.1038/sj.embor.7400201. PMC 1299112. PMID 15258613.
- Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.". Mamm. Genome 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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