Org 37,684

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Org 37,684
Systematic (IUPAC) name
(3S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine
Clinical data
Legal status Uncontrolled
Identifiers
ATC code ?
PubChem CID 9794656
IUPHAR ligand 171
Chemical data
Formula C14H19NO2 
Mol. mass 233.305 g/mol
 YesY (what is this?)  (verify)

Org 37,684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.[1][2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.[3]

See also

References

  1. ↑ Adams, D.; Duncton, M. (2001). "EFFICIENT SYNTHESIS OF THE 5-HT2C RECEPTOR AGONIST, ORG 37684". Synthetic Communications 31 (13): 2029. doi:10.1081/SCC-100104420. 
  2. ↑ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Archives of Pharmacology. 2004;370:114-123. doi:10.1007/s00210-004-0951-4 PMID 15322733
  3. ↑ Schreiber R, De Vry J. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progress in Neuropsychopharmacology and Biological Psychiatry. 2002 Apr;26(3):441-9. PMID 11999893


Antiobesity agents/Anorectics (A08)
Central
Drinabant§ • Ibipinabant§ • Otenabant§ • Rimonabant‡ • Rosonabant§ • Surinabant§ • Taranabant§
Others
5-HTP • Galactomannan (Guar gum) • Glucomannan • L-DOPA • L-Phenylalanine • L-Tryptophan • L-Tyrosine • Lorcaserin • Lu AA-33810 • Metformin • Naltrexone • Naloxone • Oxyntomodulin • P57 • Peptide YY • Topiramate • Yohimbine (Yohimbe) • Zonisamide
Peripheral

M: NUT

cof, enz, met

noco, nuvi, sysi/epon, met

drug (A8/11/12)

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