NovaMin
| Calcium sodium phosphosilicate | ||
|---|---|---|
| Properties | ||
| Molecular formula | CaNaO6PSi | |
| Molar mass | 218.123431 | |
 (verify) (what is: / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
NovaMin is the brand name of a particulate bioactive glass that is used in dental care products for remineralisation of teeth. It was developed and patented by NovaMin Technology, Inc.. The active ingredient is the inorganic chemical calcium sodium phosphosilicate.[1]
NovaMin delivers silica and ionic calcium, phosphorus, and sodium, which are necessary for bone and tooth mineralization.
How it works
NovaMin particles bind to the tooth surface and, when the particle comes in contact with saliva and water, reacts with the water to release calcium and phosphate ions. These ions are protected by glass particles so that they can be delivered to specific locations rather than as a liquid solution. Sodium ions in the particles exchange with hydrogen cations, which allows the calcium and phosphate ions to be released. A calcium phosphate layer then forms and crystallizes as hydroxylapatite, a form of hard and strong mineral in teeth. The physical occlusion of dentinal tubules results from both the hydroxylapatite layer and the residual NovaMin particles.[1][2]
The chemical reaction that leads to hydroxylapatite is:
- 5Ca2+ + 3PO43– + OH– → Ca5(PO4)3(OH)
Uses
- Treating dentine hypersensitivity[3]
- Promoting remineralisation of teeth[4]
Products Containing NovaMin
- OSspray Sylc Therapeutic Prophy Powder (US & EU)
- OSspray Sylc SmarTip Prophy System (US & EU)
- NUPRO Sensodyne Prophylaxis Paste with NovaMin, used in professional teeth cleaning by dentists and hygienists for cleaning, stain removal and sensitivity relief
- Sensodyne NUPRO Professional Toothpaste with NovaMin, dentist-dispensed toothpaste with 5,000 ppm Fluoride and NovaMin for use at home- Discontinued
- Sultan Topex Renew Paste
- DenShield (EU/Asia)
- Sultan Healthcare Topex ReNew (US)
- Dr. Collins Restore Toothpaste - No longer available as of 7 August 2013 [5](US)
- Nanosensitive hca (EU)
- Oravive No longer available as of 30 April 2010
- SensiShield (EU)
- SootheRx (US/CDN) No longer available as of 30 June 2011
- Burt's Bees Natural Toothpaste (US) - Discontinued
- SHY-NM (India)
- Vantej (India)
- Odontis-Rx (Brazil)
- X-Pur Tooth Revitalizing Paste (Canada)
- Sensodyne Repair and Protect (EU, UK, Canada and India) US version does not contain Novamin
- Sensodyne Complete Protection
Although some products are sold only through dentists, other products are available in stores or via Internet sales.
Acquisition of NovaMin by GSK
Novamin was acquired by GlaxoSmithKline in May 2010 for $135 million.[6]
See also
References
- ↑ 1.0 1.1 Comparison of RECALDENT (archived version from archive.org)
- ↑ Anti-gingivitis effect of a dentifrice containing bioactive glass (NovaMin) particulate
- ↑ A Randomized Parallel Group Clinical Study Evaluating the Efficacy of Three Desensitizing Dentifrices
- ↑ Evaluation of NovaMin as an Adjunct to Fluoride For Caries Lesion Remineralization
- ↑ http://www.drcollins.com/product-restore-toothpaste.asp
- ↑ http://www.gainesville.com/article/20100523/ARTICLES/5231002/1002