Nobiletin

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Nobiletin
IUPAC name

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

Other names

Hexamethoxyflavone

Identifiers
CAS number 478-01-3 YesY
PubChem 72344
Jmol-3D images Image 1
Properties
Molecular formula C21H22O8
Molar mass 402.39 g/mol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Nobiletin is a chemical compound. It is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine.

Medical effects

Nobiletin was found to have anti-inflammatory and anti-tumor invasion, proliferation, and metastasis in vitro and in vivo. Nobiletin was also found to potentially inhibit cartilage degradation.[1]

Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture. [2]

References

  1. ↑ Henrotin, Y.; C. Lambert, D. Couchourel, C. Ripoll, E. Chiotelli (January 2011). "Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products". Osteoarthritis and Cartilage 19 (1): 1–21. doi:10.1016/j.joca.2010.10.017. Retrieved 2011-12-27. 
  2. ↑ http://www.ncbi.nlm.nih.gov/pubmed/17976577

External links

Flavones and their conjugates
Aglycones
Monohydroxyflavone
Dihydroxyflavones
Trihydroxyflavones
Tetrahydroxyflavones
Pentahydroxyflavones
  • 6-Hydroxyluteolin
  • Hypolaetin (8-Hydroxyluteolin)
  • Tricetin (5,7,3',4',5'-Pentahydroxyflavone)
O-methylated flavones
  • Acacetin (Apigenin 4'-methyl ether)
  • Artocarpetin (Norartocarpetin 7-methyl ether)
  • Chrysoeriol (Luteolin 3'-methyl ether)
  • Cirsilineol (4',5-Dihydroxy-3',6,7-trimethoxyflavone)
  • Cirsiliol (3',4',5-trihydoxy-6,7-dimethoxyflavone)
  • Cirsimaritin (Scutellarein 6,7-dimethyl ether)
  • Diosmetin (Luteolin 4'-methyl ether)
  • Eupatilin (5,7-Dihydroxy-3',4',6-trimethoxyflavone)
  • Genkwanin (Apigenin 7-methyl ether)
  • Nepetin (Luteolin 6-methyl ether)
  • Nobiletin (3',4',5,6,7,8-Hexamethoxyflavone)
  • Oroxylin A (Baicalein 6-methyl ether)
  • Pratol (7-Hydroxy-4-methoxyflavone)
  • Salvigenin (5-Hydroxy-6,7,4'-trimethoxyflavone)
  • Sinensetin (3',4',5,6,7-Pentamethoxyflavone)
  • Tangeritin (4',5,6,7,8-Pentamethoxyflavone)
  • Techtochrysin (Chrysin 7-methyl ether)
  • Tricin (Tricetin 3',5'-dimethyl ether)
  • Wogonin (Norwogonin 8-methyl ether)
  • Zapotin (2,6,5,6-tetramethoxyflavone)
Glycosides
of apigenin
  • Apiin (Apigenin-7-O-apioglucoside)
  • Apigetrin (Apigenin 7-O-glucoside)
  • Isovitexin (Apigenin 6-C-glucoside)
  • Rhoifolin (Apigenin 7-O-neohesperidoside)
  • Saponarin (Isovitexin-7-O-glucoside)
  • Schaftoside (Apigenin 6-C-glucoside 8-C-arabinoside)
  • Vicenin-2 (Apigenin 6,8-di-C-glucoside)
  • Vitexin (Apigenin-8-C-glucoside)
of baicalein
  • Baicalin (Baicalein 7-O-glucuronide)
  • Tetuin (Baicalein 6-O-glucoside)
of hypolaetin
  • Hypolaetin 8-glucoside
  • Hypolaetin 8-glucuronide
of luteolin
  • Giraldiin A (4',5,5',7-Tetrahydroxy-3-methoxy-3'-O-α-L-arabinopyranosyloxyflavone) and B (5,5',7'-Trihydroxy-2',3-dimethoxy-4'-O-β-D-glucopyranosyloxyflavone)
  • Nepitrin (Nepetin 7-O-glucoside)
  • Oroxindin (Wogonin 7-O-glucuronide)
  • Scutellarin (Scutellarein 7-O-glucuronide)
Acetylated
  • Artocarpetin A (prenylated artocarpetin)
  • Artoindonesianin P (prenylated)
Sulfated glycosides
Theograndin I (sulfated glucuronide of isoscutellarein) and II
Polymers
Drugs


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