Nigro protocol

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Nigro protocol is the pre-operative use of chemotherapy with 5 Flourouracil and mitomycin and medical radiation for squamous cell carcinomas of less than 5 cm, followed by surgical excision if necessary.[1][2] In cases followed up with surveillance biopsies, positives can undergo salvage APR (abdomino-perineal resection). It was proposed as a non-surgical initial management for patients with anal canal squamous cell carcinoma as a means of attempting to save these patients from a lifetime management of an end colostomy bag. Dr. Nigro was Clinical Professor of Surgery at Wayne State University School of Medicine, Diplomate of the American Board of Surgery and the American Board of Colon and Rectal Surgery whose major contribution was towards advancing "the multimodality treatment of anal cancer", which has revolutionized modern colorectal disease management and has been immortalized in the literature as the Nigro Protocol.

References

  1. ↑ Al Hallak, M.Najeeb; George Hage-Nassar, Anas Mouchli (2010). "Primary Submucosal Squamous Cell Carcinoma of the Rectum Diagnosed by Endoscopic Ultrasound: Case Report and Literature Review". Case Reports in Gastroenterology 4 (2): 243–249. doi:10.1159/000319013. ISSN 1662-0631. 
  2. ↑ Nigro ND, Vaitkevicius VK, Buroker T, Bradley GT, Considine B (1981). "Combined therapy for cancer of the anal canal". Dis. Colon Rectum 24 (2): 73–5. PMID 7215078. 


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