Nephron
| Efron | |
|---|---|
 | |
| Nephron of the kidney. The labelled parts are 1. Glomerulus, 2. Efferent arteriole, 3. Bowman's capsule, 4. Proximal convoluted tubule, 5. Cortical collecting duct, 6. Distal convoluted tubule, 7. Loop of Henle, 8. Duct of Bellini, 9. Peritubular capillaries, 10. Arcuate vein, 11. Arcuate artery, 12. Afferent arteriole, 13. Juxtaglomerular apparatus. | |
| Latin | Nephroneum |
| Gray's | subject #253 1221 |
| System | Urinary system |
| Precursor | Metanephric blastema (intermediate mesoderm) |
| MeSH | Nephrons |
Types of nephrons
Two general classes of nephrons are cortical nephrons and juxtamedullary nephrons, both of which are classified according to the length of their associated Loop of Henle and location of their renal corpuscle. All nephrons have their renal corpuscles in the cortex. Cortical nephrons have their Loop of Henle in the renal medulla near its junction with the renal cortex, while the Loop of Henle of juxtamedullary nephrons is located deep in the renal medulla; they are called juxtamedullary because their renal corpuscle is located near the medulla (but still in the cortex). The nomenclature for cortical nephrons varies, with some sources distinguishing between superficial cortical nephrons and midcortical nephrons, depending on where their corpuscle is located within the cortex.[3]
The majority of nephrons are cortical. Cortical nephrons have a shorter loop of Henle compared to juxtamedullary nephrons. The longer loop of Henle in juxtamedullary nephrons create a hyperosmolar gradient that allows for the creation of concentrated urine.[4]
Anatomy
Each nephron is composed of an initial filtering component (the "renal corpuscle") and a tubule specialized for reabsorption and secretion (the "renal tubule"). The renal corpuscle filters out solutes from the blood, delivering water and small solutes to the renal tubule for modification.[citation needed]
Renal corpuscle
Composed of a glomerulus and the Bowman's capsule, the renal corpuscle (or Malphigian corpuscle) is the beginning of the nephron. It is the nephron's initial filtering component.[citation needed]
The glomerulus is a capillary tuft that receives its blood supply from an afferent arteriole of the renal circulation. The glomerular blood pressure provides the driving force for water and solutes to be filtered out of the blood and into the space made by Bowman's capsule. The remainder of the blood (only approximately 1/5 of all plasma passing through the kidney is filtered through the glomerular wall into the Bowman's capsule) passes into the efferent arteriole.The diameter of efferent arteriole is comparatively less than that of afferent arteriole, increasing the hydrostatic pressure in the glomerulus. It then moves into the vasa recta, which are only found in juxtamedullary nephrons and not cortical nephrons. The vasa recta are collecting capillaries intertwined with the loop of Henle through the interstitial space, in which the reabsorbed substances will also enter. This then combines with efferent venules from other nephrons into the renal vein, and rejoins the main bloodstream.[citation needed]
The Bowman's capsule, also called the glomerular capsule, surrounds the glomerulus. It is composed of a visceral inner layer formed by specialized cells called podocytes, and a parietal outer layer composed of simple squamous epithelium. Fluids from blood in the glomerulus are filtered through the visceral layer of podocytes, and the resulting glomerular filtrate is further processed along the nephron to form urine.[citation needed]
Renal tubule
| Renal tubule | |
|---|---|
| Latin | tubulus renalis |
| Gray's | subject #253 1223 |
The renal tubule is the portion of the nephron containing the tubular fluid filtered through the glomerulus.[5] After passing through the renal tubule, the filtrate continues to the collecting duct system, which is not part of the nephron. [6]
The components of the renal tubule are:
- Proximal convoluted tubule (lies in cortex and lined by simple cuboidal epithelium with brushed borders which help to increase the area of absorption greatly.)
- Loop of Henle (hair-pin like i.e. U-shaped and lies in medulla)
- Descending limb of loop of Henle
- Ascending limb of loop of Henle
- The ascending limb of loop of Henle is divided into 2 segments: Lower end of ascending limb is very thin and is lined by simple squamous epithelium. The distal portion of ascending limb is thick and is lined by simple cuboidal epithelium.
- Thin ascending limb of loop of Henle
- Thick ascending limb of loop of Henle (enters cortex and becomes DCT-distal convoluted tubule.)
- Distal convoluted tubule
Functions
The nephron carries out nearly all of the kidney's functions. Most of these functions concern the reabsorption and secretion of various solutes such as ions (e.g., sodium), carbohydrates (e.g., glucose), and amino acids (e.g., glutamate). Properties of the cells that line the nephron change dramatically along its length; consequently, each segment of the nephron has highly specialized functions.[citation needed]
The proximal tubule as a part of the nephron can be divided into an initial convoluted portion and a following straight (descending) portion.[7] Fluid in the filtrate entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes (primarily glucose and amino acids).[citation needed]
The loop of Henle, also called the nephron loop or the loop of Hundley, is a U-shaped tube that extends from the proximal tubule. It consists of a descending limb and ascending limb. It begins in the cortex, receiving filtrate from the proximal convoluted tubule, extends into the medulla as the descending limb, and then returns to the cortex as the ascending limb to empty into the distal convoluted tubule. The primary role of the loop of Henle is to concentrate the salt in the interstitium, the tissue surrounding the loop.[citation needed]
Considerable differences aid in distinguishing the descending and ascending limbs of the loop of Henle. The descending limb is permeable to water and noticeably less impermeable to salt, and thus only indirectly contributes to the concentration of the interstitium. As the filtrate descends deeper into the hypertonic interstitium of the renal medulla, water flows freely out of the descending limb by osmosis until the tonicity of the filtrate and interstitium equilibrate. Longer descending limbs allow more time for water to flow out of the filtrate, so longer limbs make the filtrate more hypertonic than shorter limbs.[citation needed]
Unlike the descending limb, the Thin ascending limb of loop of Henle is impermeable to water, a critical feature of the countercurrent exchange mechanism employed by the loop. The ascending limb actively pumps sodium out of the filtrate, generating the hypertonic interstitium that drives countercurrent exchange. In passing through the ascending limb, the filtrate grows hypotonic since it has lost much of its sodium content. This hypotonic filtrate is passed to the distal convoluted tubule in the renal cortex.[citation needed]
The distal convoluted tubule has a different structure and function to that of the proximal convoluted tubule. Cells lining the tubule have numerous mitochondria to produce enough energy (ATP) for active transport to take place. Much of the ion transport taking place in the distal convoluted tubule is regulated by the endocrine system. In the presence of parathyroid hormone, the distal convoluted tubule reabsorbs more calcium and secretes more phosphate. When aldosterone is present, more sodium is reabsorbed and more potassium secreted. Atrial natriuretic peptide causes the distal convoluted tubule to secrete more sodium. In addition, the tubule also secretes hydrogen and ammonium to regulate pH.[citation needed]
Collecting duct system
Each distal convoluted tubule delivers its filtrate to a system of collecting ducts, the first segment of which is the connecting tubule. The collecting duct system begins in the renal cortex and extends deep into the medulla. As the urine travels down the collecting duct system, it passes by the medullary interstitium which has a high sodium concentration as a result of the loop of Henle's countercurrent multiplier system.[citation needed]
Though the collecting duct is normally impermeable to water, it becomes permeable in the presence of antidiuretic hormone (ADH). ADH affects the function of aquaporins, resulting in the reabsorption of water molecules as it passes through the collecting duct. Aquaporins are membrane proteins that selectively conduct water molecules while preventing the passage of ions and other solutes. As much as three-quarters of the water from urine can be reabsorbed as it leaves the collecting duct by osmosis. Thus the levels of ADH determine whether urine will be concentrated or diluted. An increase in ADH is an indication of dehydration, while water sufficiency results in low ADH allowing for diluted urine.[citation needed]
Lower portions of the collecting organ are also permeable to urea, allowing some of it to enter the medulla of the kidney, thus maintaining its high concentration (which is very important for the nephron).[citation needed]
Urine leaves the medullary collecting ducts through the renal papillae, emptying into the renal calyces, the renal pelvis, and finally into the urinary bladder via the ureter.[citation needed]
Because it has a different origin during the development of the urinary and reproductive organs than the rest of the nephron, the collecting duct is sometimes not considered a part of the nephron. Instead of originating from the metanephrogenic blastema, the collecting duct originates from the ureteric bud.[citation needed]
Juxtaglomerular apparatus
The juxtaglomerular apparatus is a specialized region of the nephron responsible for production and secretion of the enzyme renin, involved in the renin-angiotensin system. This apparatus occurs near the site of contact between the thick ascending limb and the afferent arteriole. It contains three components: the macula densa, juxtaglomerular cells, and extraglomerular mesangial cells.[citation needed]
Clinical relevance
Because of its importance in body fluid regulation, the nephron is a common target of drugs that treat high blood pressure and edema. These drugs, called diuretics, inhibit the ability of the nephron to retain electrolytes (and consequently water), thereby increasing the amount of urine produced.
Additional images
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Glomerulus is red; Bowman's capsule is white.
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Kidney tissue
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Glomerulus
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This images shows the cells that make up a nephron in the kidneys. The following parts are seen: Lumen of a distal convoluted tubule (DCT), Macula densa, juxtaglomerular cells, lacis cells, mesangial cells, podocytes—visceral layer of Bowman’s capsule, parietal layer of Bowman’s capsule, lumen of a glomerular capillary, and the urinary space.
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This image shows the types of cells present in the glomerulus part of a kidney nephron. Podocytes, Endothelial cells, and Glomerular mesangial cell are present.
See also
References
- ↑ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1.
- ↑ Guyton, Arthur C.; Hall, John E. (2006). Textbook of Medical Physiology. Philadelphia: Elsevier Saunders. p. 310. ISBN 0-7216-0240-1.
- ↑ Physiology at MCG 7/7ch03/7ch03p16
- ↑ Jameson, J. Larry & Loscalzo, Joseph (2010). Harrison's Nephrology and Acid-Base Disorders. McGraw-Hill Professional. p. 3. ISBN 978-0-07-166339-7.
- ↑ Ecology & Evolutionary Biology - University of Colorado at Boulder. "The Kidney Tubule I: Urine Production." URL: http://www.colorado.edu/eeb/web_resources/cartoons/nephrex1.html. Accessed on: March 6, 2007.
- ↑ Hook, Jerry B. & Goldstein, Robin S. (1993). Toxicology of the Kidney. Raven Press. p. 8. ISBN 0-88167-885-6.
- ↑ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 743. ISBN 1-4160-2328-3.
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