Nedocromil

Nedocromil

Systematic (IUPAC) name
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Clinical data
Trade names	Alocril
AHFS/Drugs.com	monograph
MedlinePlus	a601243
Legal status	POM (UK) ℞-only (US)
Routes	Inhalation and eye drops
Pharmacokinetic data
Protein binding	89%
Metabolism	not metabolized
Half-life	~3.3 hours
Excretion	excreted unchanged
Identifiers
CAS number	69049-73-6 Y
ATC code	R01AC07 R03BC03, S01GX04
PubChem	CID 50294
DrugBank	DB00716
ChemSpider	45608 Y
UNII	0B535E0BN0 Y
KEGG	D05129 Y
ChEBI	CHEBI:7492 Y
ChEMBL	CHEMBL746 Y
Chemical data
Formula	C19H17NO7
Mol. mass	371.341 g/mol
SMILES O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC
InChI InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) Y Key:RQTOOFIXOKYGAN-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well-known inhaler medications) and as an eye drop under the brand name Alocril.^{[1] [2]} Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.^[3]

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.^[4]

References