Naloxonazine
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| Naloxonazine | ||
|---|---|---|
 | ||
| Other names NIH 10894; NSC 612113, Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride | ||
| Identifiers | ||
| CAS number | 82824-01-9  | |
| PubChem | 9576413 | |
| IUPHAR ligand | 1677 | |
| Jmol-3D images | {{#if:C=CCN1[C@H]2[C@]3([C@]4(C5=C(C2)C=CC(=C5O[C@H]4/C(=N/N=C\6/[C@@H]7OC8=C(C=CC9=C8[C@]72[C@]([C@@H](C9)N(CC2)CC=C)(CC6)O)O)/CC3)O)CC1)O|Image 1 | |
| ||
| Properties | ||
| Molecular formula | C38H42N4O6 | |
| Molar mass | 650.76 g mol−1 | |
(verify) (what is: / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
Naloxonazine is a potent irreversible mu opioid antagonist.[1] Naloxonazine forms spontaneously in acidic solutions of naloxazone, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.[2]
See also
- Oxymorphone-3-methoxynaltrexonazine (OM-3-MNZ) a similarly structured opioid also having two complete & mirrored morphinan carbon skeletons but which is a full agonist instead.[3]
References
- ↑ Naloxonazine dihydrochloride
- ↑ Hahn, E. F.; Pasternak, G. W. (September 1982). "Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites". Life Sciences 31 (12-13): 1385–1388. doi:10.1016/0024-3205(82)90387-3. PMID 6292633. Retrieved 2011-10-18.
- ↑ Image of OM-3-MNZ
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