Naftifine

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Naftifine

Systematic (IUPAC) name
(2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine
Clinical data
Trade names	Naftin
AHFS/Drugs.com	monograph
MedlinePlus	a688020
Legal status	?
Identifiers
CAS number	65472-88-0^Y
ATC code	D01AE22
PubChem	CID 47641
DrugBank	DB00735
ChemSpider	66071^N
UNII	4FB1TON47A^N
ChEMBL	CHEMBL626^N
Chemical data
Formula	C₂₁H₂₁N
Mol. mass	287.398 g/mol
N (what is this?) (verify)

Naftifine (brand name Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).

Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.^[1]^[2] The half-life is approximately 2–3 days.^[2] The metabolites are excreted in the urine and feces.^[3]

References

↑ Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
↑ 2.0 2.1 Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at http://www.thomsonhc.com/hcs/librarian/ND_T/HCS/ND_PR/Main/CS/7ED8A6/DUPLICATIONSHIELDSYNC/89971B/ND_PG/PRIH/ND_B/HCS/SBK/2/ND_P/Main/PFActionId/hcs.common.RetrieveDocumentCommon/DocId/390170/ContentSetId/100/SearchTerm/naftifine/SearchOption/BeginWith#secN10184, February 18, 2010.
↑ AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.

Antifungals (D01 and J02)

Wall/
membrane

Ergosterol
inhibitors

Azoles
(lanosterol 14
alpha-demethylase inhibitors)

Imidazoles	topical: Bifonazole Butoconazole Clomidazole Clotrimazole^#, Croconazole Econazole Fenticonazole Ketoconazole Isoconazole Miconazole^#, Neticonazole Omoconazole Oxiconazole Sertaconazole Sulconazole Tioconazole

Triazoles	topical: (Fluconazole^#, Fosfluconazole Terconazole) systemic: (Fluconazole Hexaconazole Isavuconazole^†, Itraconazole Posaconazole Voriconazole) unknown: (Albaconazole)

Thiazoles	topical: (Abafungin)

Polyene antimycotics
(ergosterol binding)

topical: (Hamycin
Natamycin
Nystatin^#)
systemic: (Amphotericin B^#, Hamycin)

Allylamines
(squalene monooxygenase
inhibitors)

β-glucan synthase
inhibitors

Intracellular

Pyrimidine analogues/ Thymidylate synthase inhibitors	Flucytosine^#

Mitotic inhibitors	Griseofulvin^#

Others

Tea tree oil
citronella oil
lemon grass
orange oil
patchouli
lemon myrtle

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: MYC

fung, clas

fung

drug (fung)

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