NS-2664

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NS-2664

Systematic (IUPAC) name
5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole
Clinical data
Legal status	?
Identifiers

ATC code	?
PubChem	CID 9840300
Chemical data
Formula	C₂₀H₁₄N₄O
Mol. mass	326.351 g/mol
SMILES c5occc5-c(cc1nc4)ccc1n4-c2cc(ccc2)-n3cncc3
Y (what is this?) (verify)

NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABA_A receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.^[1]

References

↑ Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. PMID 16352707

Anxiolytics (N05B)

GABA_A
PAMs

non-N05B	Alcohols (2M2B, Ethanol (beverage), Ethchlorvynol, Methylpentynol) Chlormezanone Etifoxine Inhalants Kavalactones (Kava) Skullcap Valerenic acid (Valerian)

Benzodiazepine	Adinazolam Alprazolam Bretazenil Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl Loflazepate Etizolam Fludiazepam Halazepam Imidazenil Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam

Carbamates	Difebarbamate Emylcamate Febarbamate Mebutamate Meprobamate (Carisoprodol, Tybamate) Phenprobamate Procymate

Nonbenzodiazepines	Abecarnil Adipiplon Alpidem CGS-8216 CGS-9896 CGS-13767 CGS-20625 Divaplon ELB-139 Fasiplon GBLD-345 Gedocarnil L-838,417 NS-2664 NS-2710 Ocinaplon Pagoclone Panadiplon Pipequaline RWJ-51204 SB-205,384 SL-651,498 Taniplon TP-003 TP-13 TPA-023 Y-23684 ZK-93423

Pyrazolopyridines	Cartazolate Etazolate ICI-190,622 Tracazolate

α₂δ VDCC Blockers

CRH₁ Antagonists

mGluR₂_/₃ Agonists

mGluR5 NAMs

TSPO agonists

σ₁ agonists

Antidepressants

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc (eval/thrp), drug (N5A/5B/5C/6A/6B/6D)

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