NLRP6
From Wikipedia, the free encyclopedia
| NLR family, pyrin domain containing 6 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NLRP6; AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; PAN3; PYPAF5 | ||||||||||||
| External IDs | OMIM: 609650 MGI: 2141990 HomoloGene: 15881 GeneCards: NLRP6 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 171389 | 101613 | |||||||||||
| Ensembl | ENSG00000174885 | ENSMUSG00000038745 | |||||||||||
| UniProt | P59044 | Q91WS2 | |||||||||||
| RefSeq (mRNA) | NM_001276700 | NM_001081389 | |||||||||||
| RefSeq (protein) | NP_001263629 | NP_001074858 | |||||||||||
| Location (UCSC) | Chr 11: 0.28 – 0.29 Mb | Chr 7: 140.92 – 140.93 Mb | |||||||||||
| PubMed search | |||||||||||||
NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[1]
References
- ↑ Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.
Further reading
- Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
- Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874.
- Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
- Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
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