NLRP5
From Wikipedia, the free encyclopedia
| NLR family, pyrin domain containing 5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NLRP5; CLR19.8; MATER; NALP5; PAN11; PYPAF8 | ||||||||||||
| External IDs | OMIM: 609658 MGI: 1345193 HomoloGene: 65105 GeneCards: NLRP5 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 126206 | 23968 | |||||||||||
| Ensembl | ENSG00000171487 | ENSMUSG00000015721 | |||||||||||
| UniProt | P59047 | Q9R1M5 | |||||||||||
| RefSeq (mRNA) | NM_153447 | NM_001039143 | |||||||||||
| RefSeq (protein) | NP_703148 | NP_001034232 | |||||||||||
| Location (UCSC) | Chr 19: 56.51 – 56.57 Mb | Chr 7: 23.39 – 23.44 Mb | |||||||||||
| PubMed search | |||||||||||||
NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.[1][2] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.
In humans, the NLRP5 protein is encoded by the NLRP5 gene.[3][4][5]
References
- ↑ Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. doi:10.1093/humrep/den403. PMID 19054779.
- ↑ Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. PMID 19815987.
- ↑ "Entrez Gene: NLR family".
- ↑ Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. PMID 11925379.
- ↑ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
Further reading
- Maraldi T, Riccio M, Sena P, et al. (2009). "MATER protein as substrate of PKCepsilon in human cumulus cells.". Mol. Hum. Reprod. 15 (8): 499–506. doi:10.1093/molehr/gap048. PMID 19542546.
- Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
- Alimohammadi M, Björklund P, Hallgren A, et al. (2008). "Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.". N. Engl. J. Med. 358 (10): 1018–28. doi:10.1056/NEJMoa0706487. PMID 18322283.
- Sena P, Riccio M, Marzona L, et al. (2009). "Human MATER localization in specific cell domains of oocytes and follicular cells.". Reprod. Biomed. Online 18 (2): 226–34. PMID 19192343.
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