NKIRAS2
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| NFKB inhibitor interacting Ras-like 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | NKIRAS2; KBRAS2; kappaB-Ras2 | ||||||||||||
| External IDs | OMIM: 604497 HomoloGene: 9738 GeneCards: NKIRAS2 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 28511 | 71966 | |||||||||||
| Ensembl | ENSG00000168256 | ENSMUSG00000017837 | |||||||||||
| UniProt | Q9NYR9 | Q9CR56 | |||||||||||
| RefSeq (mRNA) | NM_001001349 | NM_028024 | |||||||||||
| RefSeq (protein) | NP_001001349 | NP_082300 | |||||||||||
| Location (UCSC) | Chr 17: 40.16 – 40.18 Mb | Chr 11: 100.62 – 100.63 Mb | |||||||||||
| PubMed search | |||||||||||||
NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene.[1]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Normal |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal[2] |
| All tests and analysis from[3] |
Model organisms have been used in the study of NKIRAS2 function. A conditional knockout mouse line, called Nkiras2tm1a(EUCOMM)Wtsi[4][5] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[6][7][8]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[3][9] Twenty one tests were carried out, but no significant abnormalities were observed.[3]
References
- ↑ "Entrez Gene: NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30.
- ↑ "Salmonella infection data for Nkiras2". Wellcome Trust Sanger Institute.
- ↑ 3.0 3.1 3.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ "International Knockout Mouse Consortium".
- ↑ "Mouse Genome Informatics".
- ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
Further reading
- Tago K, Funakoshi-Tago M, Sakinawa M, et al. (2010). "KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.". J. Biol. Chem. 285 (40): 30622–33. doi:10.1074/jbc.M110.117028. PMID 20639196.
- Fenwick C, Na SY, Voll RE, et al. (2000). "A subclass of Ras proteins that regulate the degradation of IkappaB.". Science 287 (5454): 869–73. doi:10.1126/science.287.5454.869. PMID 10657303.
- Dieguez-Gonzalez R, Akar S, Calaza M, et al. (2009). "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.". Ann. Rheum. Dis. 68 (4): 579–83. doi:10.1136/ard.2007.087304. PMID 18434448.
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