N-Phenethyl-14-ethoxymetopon
From Wikipedia, the free encyclopedia
 | |
|---|---|
| Systematic (IUPAC) name | |
| (5α)-14-Ethoxy-3-hydroxy-5-methyl-17-(2-phenylethyl)-4,5-epoxymorphinan-6-one | |
| Clinical data | |
| Legal status | ? |
| Identifiers | |
| ATC code | ? |
| PubChem | CID 11049533 |
| Chemical data | |
| Formula | C27H31NO4 |
| Mol. mass | 433.538 g/mol |
| SMILES
| |
 (what is this?) (verify) | |
N-Phenethyl-14-ethoxymetopon is a drug that is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine and produces significantly less constipation.[1]
N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.[2]
See also
- 14-Cinnamoyloxycodeinone
- 14-Phenylpropoxymetopon
- 7-PET
- MR-2096
- N-Phenethylnormorphine
- Phenomorphan
- RAM-378
- Ro4-1539
References
- ↑ Ananthan, S (2006). "Opioid ligands with mixed μ/δ opioid receptor interactions: An emerging approach to novel analgesics". The AAPS journal 8 (1): E118–25. doi:10.1208/aapsj080114. PMC 2751430. PMID 16584118.
- ↑ Lattanzi, R; Spetea, M; Schüllner, F; Rief, SB; Krassnig, R; Negri, L; Schmidhammer, H (2005). "Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities". Journal of Medical Chemistry 48 (9): 3372–8. doi:10.1021/jm040894o. PMID 15857143.
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.