Mucoepidermoid carcinoma

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Mucoepidermoid carcinoma
Classification and external resources

Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain.
ICD-O: M8430/3
OMIM 607536
MeSH C04.557.470.200.025.340

Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid.

Mucicarmine staining is one stain used by pathologist for detection.[2]

Epidemiology

Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]

Clinical Features

Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.

Histology

This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

Molecular biology

Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.

A possible association with papillomavirus has been reported.[4]

Prognosis

Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.

Additional images

  • Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.

  • Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. The same lesion as shown in a filename "Mucoepidermoid carcinoma (2) HE stain.jpg". H & E stain.

  • Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.

References

  1. ↑ Elsevier Article Locator
  2. ↑ Modern Pathology - Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
  3. ↑ Melnick, M.; Sedghizadeh, P. P.; Allen, C. M.; Jaskoll, T. (2012). "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship". Experimental and Molecular Pathology 92 (1): 118–125. doi:10.1016/j.yexmp.2011.10.011. PMID 22101257. 
  4. ↑ Isayeva T, Said-Al-Naief N, Ren Z, Li R, Gnepp D, Brandwein-Gensler M (2012) Salivary mucoepidermoid carcinoma: Demonstration of transcriptionally active human papillomavirus 16/18. Head Neck Pathol

External links

Epithelium
Papilloma/carcinoma
(8010-8139)
Glands
Adenomas/
adenocarcinomas
(8140-8429)
Gastrointestinal
Urogenital
Endocrine
Other/multiple
Adnexal and
skin appendage (8390-8429)
Cystic, mucinous,
and serous (8440-8499)
Cystic general
Mucinous
Serous
Ductal, lobular,
and medullary (8500-8549)
Ductal carcinoma
Lobular carcinoma
Medullary carcinoma
Acinar cell (8550-8559)
Other
Complex epithelial (8560-8589)
See also
Template:Epithelium and epithelial tissue
Tumors of lip, oral cavity and pharynx / head and neck cancer (C00–C14/D10–D11, 140–149/210)
Oral cancer

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