Morphiceptin
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| Morphiceptin | |
|---|---|
 | |
| IUPAC name (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide[1] | |
| Other names Tyr-Pro-Phe-Pro-NH2, PLO17 | |
| Identifiers | |
| CAS number | 87777-29-5  |
| PubChem | 119303 |
| ChemSpider | 3754959  |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C28H35N5O5 |
| Molar mass | 521.6 g/mol |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| Infobox references | |
Morphiceptin is a tetrapeptide (Tyr-Pro-Phe-Pro-NH2) that is a selective μ-opioid receptor agonist. It is derived from β-casomorphin and has over 1,000 times selectivity for μ- over δ-opioid receptors. When injected intracerebroventricularly (into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed by naloxone, meaning that the analgesic effect is mediated by the μ-opioid receptor.[2]
See also
References
- ↑ "Morphiceptin". Morphiceptin. ChemBase. Retrieved 1 August 2011.
- ↑ Chang, K. "Analgesic activity of intracerebroventricular administration of morphiceptin and β-casomorphins: Correlation with the morphine (μ) receptor binding affinity". Life Sciences 1982 (18): 1547–1551. doi:10.1016/0024-3205(82)90242-9.
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