Michael N. Hall

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Michael N. Hall

Michael N. Hall (2011)
Born (1953-06-12) 12 June 1953
Puerto Rico
Nationality Swiss, American
Fields Molecular Biologist
Institutions University of North Carolina at Chapel Hill, Harvard University, Institut Pasteur, University of California, San Francisco, Biozentrum University of Basel

Michael Nip Hall (born 12 June 1953 in Puerto Rico) is an American and Swiss molecular biologist and Professor at the Biozentrum University of Basel, Switzerland.

Life

Hall grew up in South America (Venezuela, Peru). He earned a Bachelor of Science in Zoology from the University of North Carolina at Chapel Hill in 1976, and a PhD in Molecular Genetics from Harvard University in 1981. Hall was a postdoctoral fellow at the Institut Pasteur in Paris and at the University of California, San Francisco. He was appointed an Assistant Professor at the Biozentrum of the University of Basel in 1987, and became a Full Professor in 1992. From 1995 to 1998 and from 2002 to 2009 he was head of the Division of Biochemistry, and from 2002 until 2009 was Deputy Director of the Biozentrum.[1]

Work

Hall is a pioneer in the fields of TOR signaling and cell growth control.[2] In 1991, Hall and colleagues discovered TOR (Target of Rapamycin) and subsequently elucidated its role as a central controller of cell growth and metabolism. TOR is a conserved, nutrient- and insulin-activated protein kinase. The discovery of TOR led to a fundamental change in how one thinks of cell growth. It is not a spontaneous process that just happens when building blocks (nutrients) are available, but rather a highly regulated, plastic process controlled by TOR-dependent signaling pathways. As a central controller of cell growth and metabolism, TOR plays a key role in development and aging, and is implicated in disorders such as cancer, cardiovascular disease, diabetes, and obesity.[3]

Awards & Honors

Publication list

  • Heitman, J., N. R. Movva, and M. N. Hall. 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. In Science 253, 905-909.
  • Schmelzle, T. and M. N. Hall. 2000. TOR, a central controller of cell growth. In Cell 103, 253-262.
  • Loewith, R., E. Jacinto, S. Wullschleger, A. Lorberg, J. L. Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, and M. N. Hall. 2002. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. In Mol. Cell 10, 457-468.
  • Wullschleger, S., R. Loewith, and M. N. Hall. 2006. TOR signaling in growth and metabolism. In Cell 124, 471-484.
  • Robitaille, A. M., S. Christen, M. Shimobayashi, L. L. Fava, M. Cornu, S. Moes, C. Prescianotto-Baschong, U. Sauer, P. Jenoe, and M. N. Hall. 2013. Quantitative phosphoproteomics reveal mTORC1 phosphorylates CAD and activates de novo pyrimidine synthesis. In Science 339, 1320-1323.[13]

External links

References

  1. ↑ Curriculum Vitae Biozentrum.unibas.ch. Retrieved 2013-10-22
  2. ↑ Short Biography, De Duve Institute Retrieved 2013-10-22
  3. ↑ Introduction Michael N. Hall bioss.uni-freiburg.de Retrieved 2013-10-22
  4. ↑ European Molecular Biology Organization Membership Guide 2012 Retrieved 2013-10-22
  5. ↑ Cloëtta Prize Website Retrieved 2013-10-22
  6. ↑ 2009 Louise-Jeantet Prize for Medicine jeantet.ch Retrieved 2013-10-22
  7. ↑ Marcel Benoist Prize 2012 marcel-benoist.ch Retrieved 2013-10-22
  8. ↑ SAMS-Member samw.ch Retrieved 2013-10-22
  9. ↑ Sir Hans Krebs Lecture FEBS-EMBO 2014 Retrieved 2013-10-22
  10. ↑ First Breakthrough Prize in Life Sciences awarded to Swiss scientist. In: University of Basel, December 13, 2013
  11. ↑ "Laureates: 2014". Breakthrough Prize in Life Sciences, Retrieved 2014-02-05. 
  12. ↑ "ERC Synergy Grant: EUR 11 million for Cancer Research" In: University of Basel, December 18, 2013
  13. ↑ Publication list in Biozentrum University of Basel (biozentrum.unibas.ch); Retrieved 2013-10-22
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