MiR-144

From Wikipedia, the free encyclopedia
miR-144
Conserved secondary structure of miR-144 precursor microRNA
Identifiers
Symbol miR-144
Alt. Symbols MIR144
Rfam RF00682
miRBase MI0000460
miRBase family MIPF0000093
Entrez 406936
HUGO 31531
OMIM 612070
RefSeq NR_029685
Other data
RNA type miRNA
Domain(s) Mammalia
GO 0035195
SO 0001244
Locus Chr. 17 q11.2

miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours.

GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]

Function

miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5]

Applications

miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3]

References

  1. ↑ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential.". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 
  2. ↑ Wang, W; Peng, B, Wang, D, Ma, X, Jiang, D, Zhao, J, Yu, L (2011-10-01). "Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets.". International Journal of Cancer. Journal International Du Cancer 129 (7): 1624–34. doi:10.1002/ijc.25818. PMID 21128228. 
  3. ↑ 3.0 3.1 Zhang, X; Wang, X, Zhu, H, Zhu, C, Wang, Y, Pu, WT, Jegga, AG, Fan, GC (2010 Nov). "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.". Journal of molecular and cellular cardiology 49 (5): 841–50. doi:10.1016/j.yjmcc.2010.08.007. PMID 20708014. 
  4. ↑ Rasmussen, KD; Simmini, S, Abreu-Goodger, C, Bartonicek, N, Di Giacomo, M, Bilbao-Cortes, D, Horos, R, Von Lindern, M, Enright, AJ, O'Carroll, D (2010-07-05). "The miR-144/451 locus is required for erythroid homeostasis.". The Journal of experimental medicine 207 (7): 1351–8. doi:10.1084/jem.20100458. PMC 2901075. PMID 20513743. 
  5. ↑ Karolina, DS; Armugam, A, Tavintharan, S, Wong, MT, Lim, SC, Sum, CF, Jeyaseelan, K (2011). "MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus.". PLoS ONE 6 (8): e22839. doi:10.1371/journal.pone.0022839. PMC 3148231. PMID 21829658. 
  6. ↑ Dinan, TG (2010 Apr). "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field.". The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 13 (3): 395–404. doi:10.1017/S1461145709990800. PMID 19849891.  (subscription required)

Further reading

  • Zhang, HY; Zheng, SJ, Zhao, JH, Zhao, W, Zheng, LF, Zhao, D, Li, JM, Zhang, XF, Chen, ZB, Yi, XN (2011-04-06). "MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection.". Brain Research 1383: 62–70. doi:10.1016/j.brainres.2011.01.067. PMID 21276775. 

External links

miRNA precursor families
1-100
101-200
201+
Other
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