Metribolone
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| Metribolone | ||
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| IUPAC name 17β-17-Hydroxy-17-methyl-estra-4,9,11-trien-3-one | ||
| Other names Methyltrienolone, R1881 | ||
| Identifiers | ||
| CAS number | 965-93-5  | |
| PubChem | 261000 | |
| ChEMBL | CHEMBL166444 | |
| Jmol-3D images | Image 1 | |
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| Properties | ||
| Molecular formula | C19H24O2 | |
| Molar mass | 284.39266 | |
 (verify) (what is: /?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
| Infobox references | ||
Metribolone, (also known as methyltrienolone or R1881) is a potent, non-aromatizable androgen[1] which has also been used as a photoaffinity label for the androgen receptor.[2] It is the 17-methylated derivative of trenbolone, and is a similarly potent anabolic steroid, but with high hepatotoxicity.[3]
11 members of the Greek national weightlifting team and 4 Greek track and field athletes tested positive with methyltrienolone prior to the 2008 Beijing Olympic Games.[4]
References
- ↑ Bojar H, Maar K, Staib W (1980). "The endocrine background of human renal cell carcinoma. V. Binding of the highly potent androgen methyltrienolone (R 1881) by tumour cytosol". Urol. Int. 35 (2): 154–60. doi:10.1159/000280315. PMID 6966435.
- ↑ Brinkmann AO, Kuiper GG, de Boer W, Mulder E, Bolt J, van Steenbrugge GJ, van der Molen HJ (January 1986). "Characterization of androgen receptors after photoaffinity labelling with [3H]methyltrienolone (R1881)". J. Steroid Biochem. 24 (1): 245–9. doi:10.1016/0022-4731(86)90058-0. PMID 2422446.
- ↑ Krüskemper, HL; Noell, G (1966). "Liver toxicity of a new anabolic agent: Methyltrienolone (17-alpha-methyl-4,9,11-estratriene-17 beta-ol-3-one)". Steroids 8 (1): 13–24. PMID 5955468.
- ↑ "Eleven Greek weightlifters test positive; coach suspended". Associated Press / USATODAY.com. 2008-04-04. Retrieved 2009-06-28.
External links
- Metribolone at the US National Library of Medicine Medical Subject Headings (MeSH)
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