Methyllysine

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In proteins, the amino acid residue lysine can be methylated once, twice or thrice on its terminal sidechain ammonium group.

Such methylated lysines play an important role in epigenetics; the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones, which in turn affects the expression of genes on that DNA. The binding is affected because the effective radius of the positive charge is increased (methyl groups are larger than the hydrogen atoms they replace), reducing the strongest potential electrostatic attraction with the negatively charged DNA. Moreover, the methyl groups are themselves hydrophobic, and alter the structure of water in their vicinity, similar to tetramethyl ammonium (Jencks reference).

In Protein Data Bank files, methylated lysines are indicated by the MLY or MLZ acronyms.

  • Unmethylated lysine

  • 6-N-methyllysine

  • (6-N,6-N)dimethyllysine

  • (6-N,6-N,6-N)trimethyllysine


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