Methazolamide

Methazolamide

Systematic (IUPAC) name
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a601233
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Oral
Pharmacokinetic data
Protein binding	55%
Half-life	14 hours
Identifiers
CAS number	554-57-4 Y
ATC code	S01EC05
PubChem	CID 4100
DrugBank	DB00703
ChemSpider	3958 Y
UNII	W733B0S9SD Y
KEGG	D00655 N
ChEMBL	CHEMBL19 N
Synonyms	N-(3-Methyl-5-sulfamoyl-3H-1,3,4-thiadiazol-2-ylidene) ethanamide
Chemical data
Formula	C5H8N4O3S2
Mol. mass	236.274 g/mol
SMILES O=S(=O)(C\1=N\N(C(=N/C(=O)C)/S/1)C)N
InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4- Y Key:FLOSMHQXBMRNHR-DAXSKMNVSA-N Y
N (what is this?)  (verify)

Methazolamide (Neptazane) is a carbonic anhydrase inhibitor.

References

• Iyer G, Bellantone R, Taft D (1999). "In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics.". J Pharmacokinet Biopharm 27 (1): 45–66. doi:10.1023/A:1020630712388. PMID 10533697. 
• RxList. "Neptazane". Retrieved August 20, 2006. 
• Shirato S, Kagaya F, Suzuki Y, Joukou S (1997). "Stevens–Johnson syndrome induced by methazolamide treatment.". Arch Ophthalmol 115 (4): 550–3. PMID 9109770. 
• Skorobohach B, Ward D, Hendrix D (2003). "Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.". Am J Vet Res 64 (2): 183–7. doi:10.2460/ajvr.2003.64.183. PMID 12602587.