Mesterolone
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|---|---|
| Systematic (IUPAC) name | |
| 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Legal status | Prescription Only (AU) |
| Pharmacokinetic data | |
| Metabolism | Liver |
| Identifiers | |
| CAS number | 1424-00-6  |
| ATC code | G03BB01 |
| PubChem | CID 15020 |
| ChemSpider | 14296  |
| UNII | 0SRQ75X9I9 |
| KEGG | D04947 |
| ChEMBL | CHEMBL258918 |
| Chemical data | |
| Formula | C20H32O2 |
| Mol. mass | 304.467 g/mol |
| SMILES
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Mesterolone is an orally applicable androgen, and DHT derivative. It is sold under the brand name Proviron (as Provironum in Asia-Pacific region), by Bayer Schering Pharma (earlier by Schering). In the late 70's and early 80's it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and rarely used for replacement therapies.[1]
Trials
In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75 mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450 mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia, unipolar and bipolar depression. Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100 mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.[2]
Bodybuilding
Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.[3]
References
- ↑ Nieschlag E, Behre HM, Bouchard P, et al. (2004). "Testosterone replacement therapy: current trends and future directions". Hum. Reprod. Update 10 (5): 409–19. doi:10.1093/humupd/dmh035. PMID 15297434.
- ↑ Kövary PM, Lenau H, Niermann H, Zierden E, Wagner H (May 1977). "Testosterone levels and gonadotrophins in Klinefelter's patients treated with injections of mesterolone cipionate". Arch Dermatol Res 258 (3): 289–94. PMID 883846.
- ↑ Meso-RX Steroid Profiles - Proviron (Mesterolone)
- Morrison, Mary Chase (2000). Hormones, Gender and the Aging Brain: The Endocrine Basis of Geriatric Psychiatry. Cambridge, UK: Cambridge University Press. p. 134. ISBN 0-521-65304-5.
- Itil TM, Michael ST, Shapiro DM, Itil KZ (June 1984). "The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study)". Methods Find Exp Clin Pharmacol 6 (6): 331–7. PMID 6431212.
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