Mesangial proliferative glomerulonephritis

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Mesangial proliferative glomerulonephritis
Classification and external resources
Renal corpuscle. Intraglomerular mesangium is #5b.
ICD-10	N00.3-N08.3
DiseasesDB	31877

Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the mesangium.^[1]

There is some evidence that interleukin-10 may inhibit it in an animal model.^[2]

It is classified as type II lupus nephritis by the World Health Organization (WHO).

Mesangial cells in the renal glomerulus use endocytosis to take up and degrade circulating immunoglobulin. This normal process stimulates mesangial cell proliferation and matrix deposition. Therefore, during times of elevated circulating immunoglobulin (i.e. lupus and IgA nephropathy) one would expect to see an increased number of mesangial cells and matrix in the glomerulus. This is characteristic of nephritic syndromes.

References

↑ "Definition: mesangial proliferative glomerulonephritis from Online Medical Dictionary".
↑ Kitching AR, Katerelos M, Mudge SJ, Tipping PG, Power DA, Holdsworth SR (April 2002). "Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis". Clin. Exp. Immunol. 128 (1): 36–43. doi:10.1046/j.1365-2249.2002.01793.x. PMC 1906377. PMID 11982588.

v t e Lupus nephritis

Class I (Minimal mesangial glomerulonephritis) Class II (Mesangial proliferative lupus nephritis) Class III (Focal proliferative nephritis) Class IV (Diffuse proliferative nephritis) Class V (Membranous nephritis) Class VI (Glomerulosclerosis)

Urinary system
Pathology
Urologic disease / Uropathy (N00–N39, 580–599)

Abdominal

Nephropathy/
(nephritis+
nephrosis)

Glomerulopathy/
glomerulitis/
(glomerulonephritis+
glomerulonephrosis)

Primarily
nephrotic

Non-proliferative	Minimal change Focal segmental Membranous

Proliferative	Mesangial proliferative Endocapillary proliferative Membranoproliferative/mesangiocapillary

By condition	Diabetic Amyloidosis

Primarily
nephritic,
RPG

Type I RPG/Type II hypersensitivity	Goodpasture's syndrome

Type II RPG/Type III hypersensitivity	Post-streptococcal Lupus DPN IgA/Berger's

Type III RPG/Pauci-immune	Granulomatosis with polyangiitis Microscopic polyangiitis Churg–Strauss syndrome

Tubulopathy/
tubulitis

Proximal	RTA RTA 2 Fanconi syndrome

Thick ascending	Bartter syndrome

Distal convoluted	Gitelman syndrome

Collecting duct	Liddle's syndrome RTA RTA 1 Diabetes insipidus Nephrogenic

Renal papilla	Renal papillary necrosis

Major calyx/pelvis	Hydronephrosis Pyonephrosis Reflux nephropathy

Any/all	Acute tubular necrosis

Interstitium

Interstitial nephritis
- Pyelonephritis
- Danubian endemic familial nephropathy

Any/all

General syndromes	Renal failure Acute renal failure Chronic kidney disease Uremic pericarditis Uremia

Vascular	Renal artery stenosis Renal ischemia Hypertensive nephropathy Renovascular hypertension Renal cortical necrosis

Other	Analgesic nephropathy Renal osteodystrophy Nephroptosis Abderhalden–Kaufmann–Lignac syndrome

Ureter

Pelvic

Bladder	Cystitis Interstitial cystitis Hunner's ulcer Trigonitis Hemorrhagic cystitis Neurogenic bladder dysfunction Bladder sphincter dyssynergia Vesicointestinal fistula Vesicoureteral reflux

Urethra	Urethritis Non-gonococcal urethritis Urethral syndrome Urethral stricture/Meatal stenosis Urethral caruncle

Any/all

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte

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