Mephenoxalone

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Mephenoxalone

Systematic (IUPAC) name
5-[(2-methoxyphenoxy)methyl]-1,3-oxazolidin-2-one
Clinical data
Trade names	Dorsiflex, Moderamin, Control-OM
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	70-07-5^Y
ATC code	N05BX01
PubChem	CID 6257
ChemSpider	6021^N
UNII	CZ87T54W8W^Y
KEGG	D07318^Y
ChEMBL	CHEMBL2104790^N
Chemical data
Formula	C₁₁H₁₃N O₄
Mol. mass	223.225 g/mol
SMILES O=C2OC(COc1c(OC)cccc1)CN2
InChI InChI=1S/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)^N Key:ZMNSRFNUONFLSP-UHFFFAOYSA-N^N
N (what is this?) (verify)

Mephenoxalone (trade names Dorsiflex, Moderamin, Control-OM) is a muscle relaxant^[1] and mild anxiolytic.^[2] It inhibits neuron transmission, relaxing skeletal muscles by inhibiting the reflex arc.^{[citation needed]} As the effect of muscle relaxation, mephenoxalone affects mental condition, and is also a treatment for nervousness and anxiety.

References

↑ Magnenat, M. (1961). "The utilization in psychotherapy of a tensiolytic agent with muscle relaxant effect, Control OM (mephenoxalone), alone or associated with thymoleptics". Therapeutische Umschau. Revue therapeutique 18: 516–520. PMID 14468333.
↑ MIMS: Mephenoxalone

Anxiolytics (N05B)

GABA_A
PAMs

non-N05B	Alcohols (2M2B, Ethanol (beverage), Ethchlorvynol, Methylpentynol) Chlormezanone Etifoxine Inhalants Kavalactones (Kava) Skullcap Valerenic acid (Valerian)

Benzodiazepine	Adinazolam Alprazolam Bretazenil Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl Loflazepate Etizolam Fludiazepam Halazepam Imidazenil Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam

Carbamates	Difebarbamate Emylcamate Febarbamate Mebutamate Meprobamate (Carisoprodol, Tybamate) Phenprobamate Procymate

Nonbenzodiazepines	Abecarnil Adipiplon Alpidem CGS-8216 CGS-9896 CGS-13767 CGS-20625 Divaplon ELB-139 Fasiplon GBLD-345 Gedocarnil L-838,417 NS-2664 NS-2710 Ocinaplon Pagoclone Panadiplon Pipequaline RWJ-51204 SB-205,384 SL-651,498 Taniplon TP-003 TP-13 TPA-023 Y-23684 ZK-93423

Pyrazolopyridines	Cartazolate Etazolate ICI-190,622 Tracazolate

α₂δ VDCC Blockers

CRH₁ Antagonists

mGluR₂_/₃ Agonists

mGluR5 NAMs

TSPO agonists

σ₁ agonists

Antidepressants

Others

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc (eval/thrp), drug (N5A/5B/5C/6A/6B/6D)

Skeletal muscle relaxants (M03)

Peripherally acting
(primarily antinicotinic,
NMJ block)

Non-depolarizing

Curare alkaloids	Alcuronium Dimethyltubocurarine Tubocurarine

4° ammonium agents	ultra-short duration: Gantacurium short duration: Mivacurium Chandonium intermediate duration: Atracurium Cisatracurium Fazadinium Rocuronium Vecuronium long duration: Doxacurium Dimethyltubocurarine Pancuronium Pipecuronium Laudexium Gallamine unsorted: Hexafluronium (Hexafluorenium)

Depolarizing

Choline derivatives: Suxamethonium (Succinylcholine)

Polyalkylene derivatives: Hexamethonium

ACh release inhibitors

Botulinum toxin

Centrally acting

Carbamic acid esters	Carisoprodol Cyclarbamate Difebarbamate Febarbamate Meprobamate Methocarbamol Phenprobamate Styramate Tybamate

Benzodiazepines	Bentazepam Bromazepam Diazepam Clonazepam Flunitrazepam Lorazepam Nitrazepam Tetrazepam

Nonbenzodiazepines	Eszopiclone

Thienodiazepines	Etizolam

Quinazolines	Methaqualone

Anticholinergics (Antimuscarinics)	Cyclobenzaprine Orphenadrine

Other	Arbaclofen placarbil Baclofen Chlormezanone Chlorphenesin Chlorzoxazone Donepezil Eperisone Fenyramidol Flopropione GHB Mephenesin Mephenoxalone Metaxalone Phenibut Pridinol Promoxolane Quinine Thiocolchicoside Tizanidine Tolperisone Trazodone

Directly acting

Dantrolene

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco (m, s, c)/cong (d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

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