Meglutol

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Not to be confused with miglitol.

Meglutol

Systematic (IUPAC) name
3-hydroxy-3-methylpentanedioic acid
Clinical data
Legal status	?
Identifiers
CAS number	503-49-1^N
ATC code	C10AX05
PubChem	CID 1662
DrugBank	DB04377
ChemSpider	1600^Y
UNII	CLA99KCD53^Y
KEGG	D04897^Y
ChEBI	CHEBI:16831^Y
ChEMBL	CHEMBL50444^Y
Chemical data
Formula	C₆H₁₀O₅
Mol. mass	162.141 g/mol
SMILES O=C(O)CC(O)(C)CC(=O)O
InChI InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)^Y Key:NPOAOTPXWNWTSH-UHFFFAOYSA-N^Y
N (what is this?) (verify)

Meglutol (INN, also known as 3-hydroxy-3-methylglutaric acid, β-hydroxy-β-methylglutaric acid, and dicrotalic acid) is a hypolipidemic agent.

Lipid modifying agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1	Ezetimibe SCH-48461

Bile acid sequestrants/resins (LDL)	Cholestyramine Colestipol Colestilan Colextran Colesevelam

Liver

Statins (HMG-CoA reductase, LDL)	Simvastatin^# Atorvastatin Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Cerivastatin^‡

Niacin and derivatives (HDL and LDL)	Niceritrol Niacin Nicofuranose Aluminium nicotinate Nicotinyl alcohol Acipimox

MTTP inhibitors (VLDL)	Dirlotapide Lomitapide Mitratapide

Blood vessels

Fibrates (PPAR)	Clofibrate^‡ Bezafibrate Aluminium clofibrate Gemfibrozil Fenofibrate Simfibrate Ronifibrate Ciprofibrate Etofibrate Clofibride Clinofibrate

CETP inhibitors (HDL)	Anacetrapib^† Dalcetrapib^§ Evacetrapib^§ Torcetrapib^†

Combinations

Other

Dextrothyroxine^‡
Probucol
Tiadenol
Benfluorex
Meglutol
Omega-3-triglycerides
Magnesium pyridoxal 5-phosphate glutamate
Policosanol
Lapaquistat^§
Mipomersen
Alipogene tiparvovec

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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