Median raphe nucleus

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Brain: Median raphe nucleus
Latin nucleus raphes medianus, nucleus centralis superior
NeuroNames hier-557
NeuroLex ID birnlex_889

The median raphe nucleus (MRN) (also known as the nucleus raphes medianus (NRM) or superior central nucleus) is composed of polygonal, fusiform and piriform neurons and exists rostral to the nucleus raphes pontis.

Inhibition of the MRN in cats by lysergic acid diethylamide (LSD) and psilocin, two serotonin agonist hallucinogens, leads to dose dependent behavioral changes, indicating the MRN may be an important site of action for humans hallucinations.[1]

See also

References

  1. ↑ Trulson, M.E., Preussler DW and Trulson V.M. Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in free-moving cats. American Society for Pharmacology and Experimental Therapeutics Volume 228, Issue 1, pp. 94-102, 1 January 1984
Dorsal/
(tegmentum)
Surface
White: Sensory/ascending
White: Motor/descending
Grey: Cranial nuclei
afferent:
efferent:
Other grey
Ventral/
(base)
Grey
White: Motor/descending
Surface
Other grey: Raphe/
reticular

M: CNS

anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug (N1A/2AB/C/3/4/7A/B/C/D)

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