Mecasermin

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Mecasermin

Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Subcutaneous
Identifiers
CAS number	68562-41-4^N
ATC code	H01AC03
DrugBank	DB01277
UNII	7GR9I2683O^Y
KEGG	D04870^N
ChEMBL	CHEMBL1201716^N
Chemical data
Formula	C₃₃₁H₅₁₂N₉₄O₁₀₁S₇
Mol. mass	7648.67 g/mol
N (what is this?) (verify)

Mecasermin (INN, trade name Increlex) is recombinant human insulin-like growth factor 1 (IGF-I), which is used for the long-term treatment of growth failure in children with severe primary IGF-I deficiency.^[1]^[2]

This drug is not to be confused with mecasermin rinfabate (trade name Iplex), which is a combination of recombinant human IGF-1 (rhIGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3). IGFBP-3 serves to prolong the action of IGF-1 in the human body.

References

↑ Fintini, D; Brufani, C; Cappa, M (2009). "Profile of mecasermin for the long-term treatment of growth failure in children and adolescents with severe primary IGF-1 deficiency". Therapeutics and clinical risk management 5 (3): 553–9. PMC 2724186. PMID 19707272.
↑ "Increlex". Drugs.com. Retrieved 10 January 2010.

Hypothalamic-pituitary hormones and analogues (H01)

Hypothalamic

GNRH	Agonists: Gonadorelin Nafarelin Histrelin Antagonists: Cetrorelix Ganirelix

Somatostatin	Agonists: Lanreotide Octreotide Pasireotide Vapreotide

Anterior pituitary

ACTH	Agonists: Corticotropin Cosyntropin Tetracosactide

GH	Agonists: IGF-1 (Mecasermin/Mecasermin rinfabate) Sermorelin Somatrem Tesamorelin Antagonists: Pegvisomant

TSH	Agonists: Thyrotropin

Posterior pituitary

Oxytocin	Agonists: Carbetocin Demoxytocin Antagonists: Atosiban

Vasopressin	Agonists: Argipressin Desmopressin Felypressin Lypressin Ornipressin Terlipressin Antagonists: Conivaptan Demeclocycline Lixivaptan Mozavaptan Nelivaptan Relcovaptan Satavaptan Tolvaptan

M: END

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