Macrofilaricide

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A macrofilaricide is a chemotherapeutic compound that is active against filarial nematodes. Many nematodes are economically important parasites of human and animal.

An example is ivermectin.^[1]

References

↑ Alley WS, van Oortmarssen GJ, Boatin BA et al. (2001). "Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination". BMC Public Health 1: 12. doi:10.1186/1471-2458-1-12. PMC 60995. PMID 11734070.

Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)

Antiplatyhelmintic agents

Antitrematodals
(schistosomicides)

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Anticestodals
(taeniacides)

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Antinematodal agents
(including
macrofilaricides)

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Thiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# Pyrantel pamoate Oxantel

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^‡ quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: IFT

helm, arth (acar)

helm, arth (lice), zoon

helm, arth

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